Investigating laser patterned diagnostic assays for rapid disease detection

这个博士项目的目的是开发用于快速诊断的护理点测试。它们不仅在资源不足的发展中国家用作诊断，而且还将帮助应对抗菌素耐药性的全球挑战。该项目调查了纸基横向流动平台和激光构图技术的使用，以创建检测新的疾病生物标记物的测试。除了探索这种同时检测多个生物标记物的测试的潜在有用性外，开发的测试还将具有半定量测量标记物的能力，从而增强此类测试的临床实用性。开发工作将包括评估该测试对患者样本的诊断能力，从而创建一种可用于商业化的测试。将对多种疾病适应症的一系列生物标志物进行调查；然而，主要的重点将是创造一种诊断结核病的新测试。

The aim of this PhD project is to develop point-of-care tests for use as rapid diagnostics. They are not only for use as diagnostics in under-resourced developing countries but will also assist in tackling the global challenge of anti-microbial resistance. The project investigates the use of a paper-based lateral flow platform and a laser patterning techniques to create tests for detection of novel disease biomarkers. In addition to exploring the potential usefulness of such tests for simultaneous detection of multiple biomarkers, the tests developed will have capabilities to measure the markers semi-quantitatively, enhancing the clinical usefulness of such tests. The development work will include evaluating the tests diagnostic capabilities with patient samples thereby creating a test that could be available for commercialisation. A range of biomarkers will be investigated for multiple disease indications; however, the main focus will be to create a novel test for the diagnosis of Tuberculosis.detection