Investigating laser patterned diagnostic assays for rapid disease detection

研究用于快速疾病检测的激光图案诊断分析

• 批准号: 2225066
• 金额: --
• 依托单位: University of Southampton
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2225066
• 关键词: Investigating; laser; patterned; diagnostic; assays

The aim of this PhD project is to develop point-of-care tests for use as rapid diagnostics. They are not only for use as diagnostics in under-resourced developing countries but will also assist in tackling the global challenge of anti-microbial resistance. The project investigates the use of a paper-based lateral flow platform and a laser patterning techniques to create tests for detection of novel disease biomarkers. In addition to exploring the potential usefulness of such tests for simultaneous detection of multiple biomarkers, the tests developed will have capabilities to measure the markers semi-quantitatively, enhancing the clinical usefulness of such tests. The development work will include evaluating the tests diagnostic capabilities with patient samples thereby creating a test that could be available for commercialisation. A range of biomarkers will be investigated for multiple disease indications; however, the main focus will be to create a novel test for the diagnosis of Tuberculosis.detection

这个博士项目的目的是开发用于快速诊断的即时护理测试。它们不仅用于资源不足的发展中国家的诊断，而且还将有助于应对抗微生物药物耐药性的全球挑战。该项目研究了基于纸张的横向流动平台和激光图案化技术的使用，以创建检测新型疾病生物标志物的测试。除了探索这种测试同时检测多种生物标记物的潜在有用性外，开发的测试还将具有半定量测量标记物的能力，从而增强这种测试的临床有用性。开发工作将包括用患者样本评估测试的诊断能力，从而创建一种可用于商业化的测试。将研究多种疾病适应症的一系列生物标志物；然而，主要的焦点将是创造一种新的结核病诊断检测方法