Investigating laser patterned diagnostic assays for rapid disease detection

研究用于快速疾病检测的激光图案诊断分析

• 批准号: 2225066
• 金额: --
• 依托单位: University of Southampton
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2225066
• 关键词: Investigating; laser; patterned; diagnostic; assays

The aim of this PhD project is to develop point-of-care tests for use as rapid diagnostics. They are not only for use as diagnostics in under-resourced developing countries but will also assist in tackling the global challenge of anti-microbial resistance. The project investigates the use of a paper-based lateral flow platform and a laser patterning techniques to create tests for detection of novel disease biomarkers. In addition to exploring the potential usefulness of such tests for simultaneous detection of multiple biomarkers, the tests developed will have capabilities to measure the markers semi-quantitatively, enhancing the clinical usefulness of such tests. The development work will include evaluating the tests diagnostic capabilities with patient samples thereby creating a test that could be available for commercialisation. A range of biomarkers will be investigated for multiple disease indications; however, the main focus will be to create a novel test for the diagnosis of Tuberculosis.detection

这个博士项目的目的是开发用于快速诊断的即时检测。它们不仅可用于资源不足的发展中国家的诊断，而且还将有助于应对抗微生物耐药性的全球挑战。该项目研究使用基于纸的横向流动平台和激光图案化技术来创建检测新型疾病生物标志物的测试。除了探索这种测试用于同时检测多种生物标志物的潜在有用性之外，所开发的测试将具有半定量测量标志物的能力，从而增强这种测试的临床有用性。开发工作将包括评估患者样本的测试诊断能力，从而创建可用于商业化的测试。将针对多种疾病适应症研究一系列生物标志物;然而，主要重点将是创建一种用于诊断结核病的新型检测方法。