Community Health Effects of Industrial Hog Operations

描述（由申请人提供）： 最近大规模封闭式动物饲养操作（CAFO）的扩展是 在美国和其他国家引起了广泛的健康问题。 来自猪CAFO的空气和地下水污染特别令人关注， 北卡罗来纳州，自2000年以来， 80年代 空气中的排放物由数百种物质组成， 硫化氢、氨、挥发性有机化合物和粉尘，或 含有生物材料的颗粒物质，包括蛋白质和 内毒素 硝酸盐、病原体和抗生素残留物已被记录在案 在猪圈附近的地下水里 调查人员提出了一系列 以社区为基础的参与性研究，将（1）量化社区 暴露于硫化氢、挥发性有机化合物、粉尘， 内毒素;（2）评估空气排放和感知之间的关系 气味和刺激;（3）测量暴露于空气中的排放物， 畜牧业行动，以加强已经资助的卫生设计 症状调查;和（4）前瞻性地量化周围环境之间的关系 暴露和呼吸道症状、肺功能和其他健康状况 对居住在北卡罗来纳州猪CAFO附近的人采取措施。 他们将 并（5）监测水井中的硝酸盐和抗生素残留 研究参与者的水。 报告以下情况的任何参与者的细菌植物群： 受兽药残留污染的饮用水历史将 进行抗生素耐药性测试 由于对生物医学的普遍不信任， 在NC猪CAFO所在的穷人和有色人种社区进行的研究 需要集中的、以社区为基础的参与性研究方法 来解决这些健康问题。 拟议的研究建立在五年 由关心的Tillery公民进行的社区驱动的研究， 北卡罗来纳州大学公共卫生学院，以及 广泛研究化学气味及其影响，以及水 质量，由其他项目合作者进行。 本项目将提供 关于猪CAFO暴露和人类健康影响的新科学数据， 提高北卡罗来纳州东部社区改善公共卫生的能力 在美国的一个不发达地区。

DESCRIPTION (provided by applicant): Recent expansion of large scale confined animal feeding operations (CAFOs) is generating a wide variety of health concerns in the USA and other nations. Air and ground water pollution from swine CAFOs are of particular concern in North Carolina, where industrial hog production has expanded rapidly since the 1980s. Airborne emissions are composed of hundreds of agents including hydrogen sulfide, ammonia, volatile organic compounds, and dusts or particulate matter that contains biological materials including proteins and endotoxins. Nitrates, pathogens, and antibiotic residues have been documented in ground water near swine CAFOs. The investigators propose a series of community-based participatory studies that will (1) quantify community exposures to hydrogen sulfide, volatile organic compounds, dusts, and endotoxins; (2) evaluate relationships between air emissions and perceptions of odor and irritation; (3) measure exposures to airborne emissions from livestock operations to strengthen the design of an already-funded health symptom survey; and (4) prospectively quantify relationships between ambient exposures and respiratory symptoms, lung function, and other health status measures among persons residing near swine CAFOs in North Carolina. They will also (5) conduct surveillance for nitrates and antibiotic residues in well water of study participants. Bacterial flora of any participants who report a history of drinking water contaminated by veterinary antibiotic residues will be tested for antibiotic resistance. Due to widespread distrust of biomedical research in poor and people of color communities where NC swine CAFOs are concentrated, community-based participatory research approaches are required for addressing these health issues. The proposed studies build on five years of community-driven research conducted by Concerned Citizens of Tillery and the University of North Carolina School of Public Health, as well as on extensive research on chemical odorants and their effects, and on water quality, conducted by other project collaborators. This project will provide new scientific data on exposures and human health effects of swine CAFOs and increase the capacity of communities in eastern NC to improve public health conditions in an underdeveloped region of the United States.