Community Health Effects of Industrial Hog Operations

描述（由申请人提供）： 最近大规模封闭式动物饲养场 (CAFO) 的扩张 在美国和其他国家产生了各种各样的健康问题。 养猪集中饲养场造成的空气和地下水污染尤其令人担忧 北卡罗来纳州自20世纪90年代以来工业化生猪生产迅速扩大 20 世纪 80 年代。 空气中的排放物由数百种物质组成，包括 硫化氢、氨、挥发性有机化合物和灰尘或 颗粒物含有生物材料，包括蛋白质和 内毒素。 硝酸盐、病原体和抗生素残留已被记录 猪集中饲养场附近的地下水中。 研究人员提出了一系列 基于社区的参与性研究将 (1) 量化社区 暴露于硫化氢、挥发性有机化合物、灰尘和 内毒素； (2)评估空气排放与感知之间的关系 气味和刺激； (3) 测量空气中排放物的暴露量 畜牧业经营，以加强已经资助的卫生保健的设计 症状调查； (4) 前瞻性地量化环境之间的关系 暴露和呼吸道症状、肺功能和其他健康状况 对北卡罗来纳州养猪集中饲养场附近居住者采取的措施。 他们会 (5) 对井中硝酸盐和抗生素残留进行监测 研究参与者的水。 报告细菌菌群的任何参与者 饮用水被兽用抗生素残留污染的历史 进行抗生素耐药性测试。 由于人们对生物医学的普遍不信任 对 NC 猪 CAFO 所在的穷人和有色人种社区进行研究 需要集中、以社区为基础的参与性研究方法 来解决这些健康问题。 拟议的研究建立在五年的基础上 由关心蒂勒里公民进行的社区驱动研究和 北卡罗来纳大学公共卫生学院以及 对化学气味剂及其影响以及水的广泛研究 质量，由其他项目合作者进行。 该项目将提供 关于猪 CAFO 的暴露和人类健康影响的新科学数据 提高北卡罗来纳州东部社区改善公共卫生的能力 美国欠发达地区的情况。

DESCRIPTION (provided by applicant): Recent expansion of large scale confined animal feeding operations (CAFOs) is generating a wide variety of health concerns in the USA and other nations. Air and ground water pollution from swine CAFOs are of particular concern in North Carolina, where industrial hog production has expanded rapidly since the 1980s. Airborne emissions are composed of hundreds of agents including hydrogen sulfide, ammonia, volatile organic compounds, and dusts or particulate matter that contains biological materials including proteins and endotoxins. Nitrates, pathogens, and antibiotic residues have been documented in ground water near swine CAFOs. The investigators propose a series of community-based participatory studies that will (1) quantify community exposures to hydrogen sulfide, volatile organic compounds, dusts, and endotoxins; (2) evaluate relationships between air emissions and perceptions of odor and irritation; (3) measure exposures to airborne emissions from livestock operations to strengthen the design of an already-funded health symptom survey; and (4) prospectively quantify relationships between ambient exposures and respiratory symptoms, lung function, and other health status measures among persons residing near swine CAFOs in North Carolina. They will also (5) conduct surveillance for nitrates and antibiotic residues in well water of study participants. Bacterial flora of any participants who report a history of drinking water contaminated by veterinary antibiotic residues will be tested for antibiotic resistance. Due to widespread distrust of biomedical research in poor and people of color communities where NC swine CAFOs are concentrated, community-based participatory research approaches are required for addressing these health issues. The proposed studies build on five years of community-driven research conducted by Concerned Citizens of Tillery and the University of North Carolina School of Public Health, as well as on extensive research on chemical odorants and their effects, and on water quality, conducted by other project collaborators. This project will provide new scientific data on exposures and human health effects of swine CAFOs and increase the capacity of communities in eastern NC to improve public health conditions in an underdeveloped region of the United States.