Exploring the activation mechanisms of pentameric ligand gated ion channels (pLGICs) by atomistic simulations and single channel methods

通过原子模拟和单通道方法探索五聚配体门控离子通道（pLGIC）的激活机制

• 批准号: 2241759
• 金额: --
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2241759
• 关键词: Exploring; activation; mechanisms; pentameric; ligand

pLGICs are important neuroreceptors, embedded in neuronal membranes where they mediate fast synaptic communication. They are involved in many neurological disorders and are targets sites for drugs. However, due to their complexity and the limited structural information available, how they function at the molecular level is still far from being fully understood. In this PhD project we will focus on a specific pLGIC, the glycine receptor, with the goal to understand how the binding of glycine activates the receptor and opens its channel. We will achieve this by a unique combination of innovative computational techniques and single channel experiments.

pLGIC是重要的神经受体，嵌入神经元膜中，在那里它们介导快速突触通信。它们与许多神经系统疾病有关，是药物的靶点。然而，由于它们的复杂性和有限的结构信息，它们如何在分子水平上发挥作用仍然远未被完全理解。在这个博士项目中，我们将专注于一个特定的pLGIC，甘氨酸受体，目的是了解甘氨酸的结合如何激活受体并打开其通道。我们将通过创新的计算技术和单通道实验的独特组合来实现这一目标。