Understanding the antimicrobial activity of amyloid peptides

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Microbial attack on the brain has been suggested as a potential root-cause for dementia,including Alzheimer's disease (AD), which is now the second leading cause of death in the UK.The defining diagnostic marker of AD is the presence of amyloid-Beta (ABeta) plaques in the brain.The precise physiological role of these plaques remains unclear, but recent work issuggesting a direct connection to bacterial infiltration of the brain. In this project you willexplore the antimicrobial properties of ABeta peptides and determine their mechanisms ofactivity.