Understanding the antimicrobial activity of amyloid peptides

了解淀粉样肽的抗菌活性

• 批准号: 2241994
• 金额: --
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2241994
• 关键词: Understanding; antimicrobial; activity; amyloid; peptides

Microbial attack on the brain has been suggested as a potential root-cause for dementia,including Alzheimer's disease (AD), which is now the second leading cause of death in the UK.The defining diagnostic marker of AD is the presence of amyloid-Beta (ABeta) plaques in the brain.The precise physiological role of these plaques remains unclear, but recent work issuggesting a direct connection to bacterial infiltration of the brain. In this project you willexplore the antimicrobial properties of ABeta peptides and determine their mechanisms ofactivity.

微生物对大脑的攻击被认为是痴呆症的潜在根源，包括阿尔茨海默氏病（AD），它现在是英国的第二大死因。AD的定义诊断标志是大脑中淀粉样β蛋白（ABeta）斑块的存在。这些斑块的确切生理作用尚不清楚，但最近的研究表明与细菌浸润大脑有直接联系。在这个项目中，你将探索ABeta肽的抗菌特性，并确定它们的作用机制。