Nursing Inquiry: Stress & Immune Response with Battering

护理询问：压力

• 批准号: 6637353
• 负责人: Stephanie J Woods
• 金额: $ 10.36万
• 依托单位: UNIVERSITY OF AKRON
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-15 至 2004-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6637353
• 关键词: behavioral /social science research tag; child abuse; cortisol; early experience; female; human subject; leukocyte count; nursing research; patient oriented research; posttraumatic stress disorder; psychological models; psychoneuroimmunology; spouse abuse; violence; women's health

DESCRIPTION: (provided by applicant) Research with clinical- and population-based samples has shown that at least 60 percent of battered women experience posttraumatic stress disorder (PTSD). While changes in cortisol levels, immune status, and long-term health consequences associated with PTSD have been studied in several trauma survivor groups, there has been little such research with women in general, and battered women in particular. Additionally, there is a paucity of literature identifying specific predictors of PTSD symptoms in battered women. The purpose of this study is to examine the relationship between and among intimate partner violence, trauma history, PTSD symptomatology, cortisol levels, and immune status in battered women. The specific aims are to: 1) identify which empirical indicators of intimate partner violence (actual physical violence, emotional abuse, sexual violence, risk of homicide, threats of violence, and length of abusive relationship) are more predictive of PTSD symptoms in battered women; 2) examine the relative effects of childhood maltreatment and adult trauma history on PTSD symptoms in battered women; 3) examine childhood maltreatment as a moderator of PTSD symptoms in battered women; 4) describe immune status via leukocyte count, lymphocyte subset counts (CD4 cell, CD8 cell, B-cell, and natural killer cell), CD4:CD8 ratio, number of viral illnesses the past 6 months, and IgA levels in battered women; 5) examine the relationship between PTSD symptoms and salivary cortisol levels in battered women; and 6) examine the relationship between intimate partner violence, trauma history, PTSD symptoms, cortisol levels, and immune status in battered women. The theoretical interrelationships among the model constructs delineated in the specific aims will be examined in a sample of 135 battered women from shelters and the community. The soft modeling, or Least Variable Path Analysis with Partial Least Squares, approach to structural equation modeling and multiple regression will be used to test the specified relationships among the model constructs in the proposed model. The proposal also aims to enhance the development of the investigator as a nurse scientist with the advanced clinical and statistical skills needed to investigate the complex interrelationships between physiologic and psychosocial responses to intimate violence. The investigator?s long-term objectives are to develop, refine, and/or expand holistic interventions with the goal of delaying the onset and progression of disease in persons experiencing chronic stress as a result of violence or trauma.

描述：（由申请人提供）临床研究和 基于人口的样本显示，至少60%的受虐妇女 经历创伤后应激障碍（PTSD）。皮质醇的变化 水平、免疫状态和与PTSD相关的长期健康后果 已经在几个创伤幸存者群体中进行了研究，很少有这样的 对一般妇女，特别是被殴打的妇女进行研究。此外，本发明还 缺乏识别PTSD特定预测因子的文献 受虐妇女的症状本研究的目的是探讨 亲密伴侣暴力、创伤史、PTSD之间的关系 受虐妇女的行为学、皮质醇水平和免疫状态。的 具体目标是：1）确定哪些经验指标的亲密 伴侣暴力（实际的身体暴力、精神虐待、性暴力， 杀人的风险，暴力威胁，虐待关系的长度）是 更多的预测创伤后应激障碍症状的受虐妇女; 2）检查相对 儿童期虐待和成人期创伤史对创伤后应激障碍症状的影响 受虐妇女; 3）研究童年虐待作为PTSD的调节剂 受虐妇女的症状; 4）通过白细胞计数描述免疫状态， 淋巴细胞亚群计数（CD 4细胞、CD 8细胞、B细胞和自然杀伤细胞）， CD 4：CD 8比率，过去6个月病毒性疾病的数量，以及伊加水平， 受虐妇女; 5）检查PTSD症状与唾液分泌之间的关系 被虐妇女的皮质醇水平;及6）研究 亲密伴侣暴力，创伤史，PTSD症状，皮质醇水平， 受虐妇女的免疫状况 本报告所述模型结构之间的理论相互关系 将对收容所的135名受虐妇女进行抽样调查， 和整个社区软建模，或最小变量路径分析 偏最小二乘法，结构方程建模方法和多重 回归将用于测试模型之间的指定关系 在提出的模型中。 这项建议亦旨在加强调查员作为 护士科学家与所需的先进的临床和统计技能， 研究生理和社会心理之间复杂的相互关系 对亲密暴力的反应那个调查员的长期目标是 制定、完善和/或扩大整体干预措施， 在经历慢性压力的人中疾病的发作和进展， 暴力或创伤的结果。

项目成果

Predicting immune status in women from PTSD and childhood and adult violence.

预测女性免受创伤后应激障碍（PTSD）以及儿童和成人暴力的免疫状态。

• DOI: 10.1097/00012272-200510000-00003
• 发表时间: 2005
• 期刊: ANS. Advances in nursing science
• 作者: Woods,StephanieJ;Wineman,NMargaret;Page,GayleG;Hall,RosalieJ;Alexander,ThomasS;Campbell,JacquelynC
• 通讯作者: Campbell,JacquelynC