EVALUATION OF DIAGNOSTIC TESTS FOR PEDIATRIC SLEEP APNEA

小儿睡眠呼吸暂停诊断测试的评估

• 批准号: 6615785
• 负责人: CAROL Lynn ROSEN
• 金额: $ 12.7万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-01 至 2005-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6615785
• 关键词: clinical research; diagnosis design /evaluation; health economics; home health care; human morbidity; human subject; mathematical model; method development; middle childhood (6-11); model design /development; monitoring device; outcomes research; patient monitoring device; polysomnography; preschool child (1-5); prognosis; quality of life; questionnaires; respiratory disorder diagnosis; sleep apnea; statistics /biometry

The candidate is an experienced academic clinician, trained in pediatric pulmonology and sleep medicine, who plans to re-train in clinical epidemiology. This award is expected to help transition the candidate's focus from physiological testing to clinical epidemiology. The candidate's career goals are to develop an independent research career concentrating on the identification, diagnosis, treatment, and outcomes assessment of obstructive sleep apnea (OSA) in children. The specific objective of the research proposal is the rigorous systematic assessment (reliability, accuracy, and cost effectiveness) of a diagnostic strategy for OSA in children that relies on clinical predictors and simplified home (unattended) monitoring. The candidate proposes a five-year training program with an experienced team of faculty mentors from strong research departments. This plan describes activities (advanced degree coursework, independent study, patient based clinical research) focused on developing skills in clinical epidemiology with immediate applications to the diagnosis of sleep disordered breathing in children. Specific activities in the plan include research training in statistical methods, experience with data analysis in large databases, supervised experience in preparation of grant proposals for individual research support, and training in the responsible conduct of research. The proposed research addresses important knowledge gaps about diagnostic testing for OSA in children and provides important new data for rational and cost-effective application of technology to an under-recognized health condition of children. Furthermore, clarification of the role of diagnostic testing and outcome assessment in pediatric OSA will be crucial for future randomized controlled trials of treatment efficacy; mechanistic studies, and population based studies of pediatric sleep disorder breathing. Finally, the proposal will provide a key training opportunity to foster the candidate's career development as a clinical epidemiologist with a commitment to patient based research in pediatric sleep medicine and pulmonology.

候选人是一位经验丰富的学术临床医生，接受过儿科肺病学和睡眠医学方面的培训，计划重新培训临床流行病学。这一奖项有望帮助候选人将重点从生理测试转移到临床流行病学。候选人的职业目标是发展一个独立的研究生涯，专注于儿童阻塞性睡眠呼吸暂停(OSA)的识别、诊断、治疗和结果评估。该研究提案的具体目标是对儿童阻塞性睡眠呼吸暂停综合征的诊断策略进行严格的系统评估(可靠性、准确性和成本效益)，该策略依赖于临床预报器和简化的家庭(无人值守)监测。候选人提出了一个为期五年的培训计划，由来自强大研究部门的经验丰富的教师导师团队组成。该计划描述了以培养临床流行病学技能为重点的活动(高级学位课程、独立研究、以病人为基础的临床研究)，并立即将其应用于儿童睡眠呼吸障碍的诊断。该计划的具体活动包括统计方法研究培训、大型数据库数据分析经验、为个别研究支助编写赠款提案的监督经验，以及负责任地开展研究的培训。拟议的研究填补了有关儿童阻塞性睡眠呼吸暂停综合征诊断检测的重要知识空白，并为合理和经济有效地将技术应用于认识不足的儿童健康状况提供了重要的新数据。此外，阐明诊断测试和结果评估在儿童阻塞性睡眠呼吸暂停中的作用将是未来治疗效果的随机对照试验、机制研究和基于人群的儿童睡眠障碍呼吸研究的关键。最后，该提案将提供一个关键的培训机会，促进候选人作为一名临床流行病学家的职业发展，致力于儿科睡眠医学和肺病学方面的以患者为基础的研究。