Core--Primate research laboratory

核心A.灵长类研究实验室 这个核心单位通过与Axion研究基金会达成的联盟协议提供资金，提供灵长类动物、胎儿组织、实验室设施、必要的设备和支持人员，以在猴子身上进行活体动物实验。自从该设施在资助该项目之前在猴子身上进行了第一次成功的神经移植以来，它一直是该项目的关键组成部分。 这项提案的三个项目中提出的研究需要对非人类灵长类动物进行研究，以增加所获得的科学知识和开发的技术应用于人类神经系统及其疾病的可能治疗的可能性。根据先前的经验、先前实验的估计效应大小和可变性以及本提案中描述的科学原理，这些研究将需要大量特定年龄的猴子和胚胎。因此，这一设施的独特之处在于，它有能力在所需的水平上进行这些研究，这不仅是因为灵长类来源国有可用的动物资源，而且因为有经验丰富、敬业的工作人员和 为动物护理和研究数据收集提供必要支持的兽医。 虽然这是一个单独的实验室，但项目和实验实际上都将由该计划的高级调查人员或在他们的直接监督下进行。

CORE A. PRIMATE RESEARCH LABORATORY This Core Unit, funded through a Consortium agreement with the Axion Research Foundation, provides primates, fetal tissue, laboratory facilities, necessary equipment, and supporting staff to carry out atl of the live-animal experiments in monkeys. It has been a key component of this program since the first successful neural transplants were carried out in monkeys at this facility prior to the funding of this program. The research proposed in the three projects of this proposal requires studies in nonhuman primates in order to increase the probability that the scientific knowledge gained and the techniques developed will be applicable to the human nervous system and possible treatments of its disorders. Based on prior experience, estimated effect sizes and variability from prior experiments, and the scientific rationales described in this proposal, these studies will require a large number of monkeys and embryos of specific ages. This facility, therefore, is unique in its ability to carry out these studies at the required level, not only because of the animal resources available in a primate source country, but because of the experienced, dedicated staff and veterinarians who provide the necessary support for animal care and research data collection. Although this is a separate laboratory, the projects and experiments wilt all actually be carried out by the senior investigators of the program or under their direct supervision.