Boron-Directed C-H Activation: Double Direct Functionalisation of CH Bonds

硼引导的 C-H 活化：CH 键的双重直接官能化

• 批准号: 2250177
• 金额: --
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2250177
• 关键词: Boron; Directed; Activation; Double; Direct

Organic molecules contain multiple carbon-hydrogen (C-H) bonds, so achieving a selective reaction at only one site is very challenging. Metal-catalysed reactions of C-H bonds can offer a potentially powerful approach both to the functionalisation of entirely unactivated bulk chemicals (hydrocarbons, arenes), and for late-stage functionalisation of complex molecules such as pharmaceuticals, provided selectivity can be achieved. In this project, we will examine a new approach where we will use a boron group in an organic molecule to control the selectivity of metal-catalysed C-H functionalisation reactions. A range of structurally novel boron compounds will be synthesised and their reactivity in C-H activation reactions explored. As carbon-boron bonds are very versatile in their ability to undergo a variety of highly selective chemical reactions, the products of our new C-H functionalisation reactions will then be examined as useful building blocks for organic chemistry.The research project falls within the EPSRC areas of Catalysis and Synthetic Organic Chemistry within the Physical Sciences research theme. The technology developed in this project could find application within the EPSRC themes of Healthcare Technologies and Manufacturing the Future by facilitating the future design and development of novel pharmaceuticals.

有机分子含有多个碳氢键，因此仅在一个位点上实现选择性反应是非常具有挑战性的。金属催化的C-H键反应可以为完全未活化的散装化学品（碳氢化合物，芳烃）的功能化和复杂分子（如药物）的后期功能化提供潜在的强大方法，前提是可以实现选择性。在这个项目中，我们将研究一种新的方法，我们将在有机分子中使用硼基团来控制金属催化的碳氢功能化反应的选择性。一系列结构新颖的硼化合物将被合成，并在C-H活化反应中探索其反应活性。由于碳硼键具有多种高度选择性的化学反应能力，因此我们的新碳氢功能化反应的产物将作为有机化学的有用组成部分进行研究。该研究项目属于EPSRC物理科学研究主题下的催化和合成有机化学领域。在这个项目中开发的技术可以通过促进未来新型药物的设计和开发，在EPSRC的医疗保健技术和未来制造主题中找到应用。