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Core--molecular biomarkers facility

Core--molecular biomarkers facility
核心——分子生物标志物设施
批准号：
6564486
负责人：
PAUL J HAGERMAN
金额：
$17.91万
依托单位：
UNIVERSITY OF CALIFORNIA AT DAVIS
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
项目状态：
已结题
起止时间：
2001-09-30 至 2002-09-29
来源：
https://reporter.nih.gov/project-details/6564486
关键词：
animal tissue autism biomarker biomedical facility clinical research environmental exposure human tissue microarray technology neurotoxins

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DESCRIPTION (provided by applicant) The principal goal of the Molecular Biomarkers Core is to identify patterns of altered gene expression that form a significant association with autism in human populations, or which are coupled to specific environmental factors in animal models. The core will utilize both broad-spectrum and focused microarrays to support the human and animal studies described in Research Projects I-III. To meet these needs, Core II will provide uniform handling, extraction, and isolation of mRNA from tissue samples generated by Center investigators. In addition, the core will use both human and mouse genomic libraries to create targeted microarrays. An essential component of the Core s efforts will be to further develop methods of analysis for microarray data in an effort to both better define, and reduce the errors associated with the interpretation of microarray information.
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