Meconium markers of fetal neurotoxicant exposures

描述（由申请人提供） 环境毒物与许多发育中的 紊乱不幸的是，这些暴露对健康的影响 发生在实际接触之后很久。对于胎儿，暴露估计值为 由于难以获得用于分析的组织而特别困难。 低至中度暴露于环境毒物的生物标志物，如 以及这些药物对神经发育不良影响的生物标志物， 暴露将允许早期识别和干预受影响的 婴儿，识别有接触风险的妇女，并促进关于 混合物的环境暴露之间的剂量-反应关系 毒物和其他已知的发育神经毒物（乙醇和 尼古丁）和神经发育结果。胎粪，第一次大便经过 一名新生儿被用来确定是否接触过滥用药物。的 据报道，胎粪中存在环境毒物。研究 在研究者的实验室中， 胎粪中脂肪酸乙酯（乙醇代谢物）的量， 母亲自我报告的低至中度饮酒水平， 妊娠与婴儿在Bayley婴儿量表上的表现 在6、12和24个月大时的发育。该提案旨在解决 假设环境毒物以及尼古丁和乙醇 胎粪中的代谢物是暴露于 发育神经毒物，并可能表明婴儿的风险， 神经发育，通过实现以下2个具体目标：1）确定一个 准确分析和比较6类神经毒物的方法， 一份胎粪样本2)描述这些神经毒物的存在 在400名婴儿的队列中（项目1），并描述他们与 采取的更传统的产妇和环境措施， 项目1。项目1的目标是描述胎粪措施的特点， 神经发育结果。这些研究将利用患者队列， 项目1所述的产妇/婴儿/环境措施，胎粪 从已知的禁酒主义者和随机胎粪从我们的婴儿托儿所。这些 研究将提供关于可行性和效用的初步数据， 胎粪分析，以评估环境神经毒物对 人类胎儿

DESCRIPTION (provided by applicant) Environmental toxicants have been implicated in a number of developmental disorders. Unfortunately, the health effects subscribed to these exposures occurs long after the actual exposure. For fetuses, exposure estimates are particularly difficult due to the difficulty of obtaining tissue for analysis. Biological markers for low to moderate exposure to environmental toxicants, as well as biological markers for adverse neurodevelopmental effects of these exposures would allow earlier identification and intervention for affected infants, recognition of women at risk for exposure, and facilitate research on dose-response relationships between environmental exposures to mixtures of toxicants and to other known developmental neurotoxicants (ethanol and nicotine) and neurodevelopmental outcome. Meconium, the first stool passed by a newborn, has been used to establish exposure to drugs of abuse. The presence of environmental toxicants in meconium has been reported. Research in the investigators laboratory has shown a significant associations between the quantity of fatty acid ethyl esters (ethanol metabolites) in meconium and both maternal self-reported low to moderate levels of drinking during pregnancy and the infants performance on the Bayley Scales of Infant Development at 6, 12, and 24 months of age. This proposal seeks to address the hypothesis that environmental toxicants as well as nicotine and ethanol metabolites in meconium are useful biological markers for exposure to developmental neurotoxicants, and may indicate infants at risk for poor neurodevelopment, by achieving the following 2 specific aims: 1) Determine a methodology to accurately analyze and compare 6 classes of neurotoxicants in a single sample of meconium. 2) Describe the presence of these neurotoxicants in a cohort of 400 infants (Project 1) and characterize their relationship to more traditional maternal and environmental measures obtained as part of Project 1. Project 1 will aim to characterize the meconium measures with neurodevelopmental outcome. These studies will utilize the patient cohort and maternal/infant/environmental measures as described in Project 1, meconium from known teetotalers and random meconium from our well baby nursery. These studies will provide preliminary data on the feasibility and utility of meconium analysis to gauge the influence of environmental neurotoxicants on human fetuses.