MOLECULAR MECHANISTIC BASIS FOR RADIATION INDUCED PULMONARY LATE EFFECTS

描述：(申请者？S描述)这个项目的总体目标是 旨在加深对分子机制的理解 是正常组织迟发效应的基础，在 放射后的肺。以前的CERIS项目已经导致了这一范例 辐射迟发效应依赖于采取 位于多个受损细胞之间，而不是经典的 单一目标单元格。为了追求这一目标，他们的意思是进一步定义 对话，他们假设这是一个“细胞因子级联反应”，在 促炎症和促纤维化的空间和时间释放 细胞因子和生长因子及其遗传背景。这一点的扩展 范式使他们假设免疫系统在 晚期组织效应的发展，这一点将被更详细地探讨。 调节细胞因子级联反应(S)和/或免疫系统 研究既是阐明特定细胞因子作用的一种手段， 以及提出改进的途径。

Description: (Applicant?s Description)The general goal of this program is directed at gaining a deeper understanding of the molecular mechanisms which are the basis for the normal tissue late effects which are observed in the lung following radiation. Previous CERRIS programs have led to the paradigm of radiation late effects being dependent upon the "conversation" which takes place between a number of injured cells, rather than the classic concept of a single target cell. In pursuit of this goal, they mean to further define the conversation, which they have hypothesized as a "cytokine cascade", in terms of the spatial and temporal release of proinflammatory and profibrotic cytokines and growth factors, and their genetic context. Expansion of this paradigm has led them to postulate the role of the immune system in the development of late tissue effects and this will be explored in more detail. Modulation of the cytokine cascade(s) and/or the immune system will be investigated as a means of both elucidating the roles of specific cytokines, as well as suggesting routes of amelioration.