Opioid Receptor Imaging by PET in Bulimia Nervosa

神经性贪食症阿片受体 PET 成像

• 批准号: 6572686
• 负责人: James JAMES FROST
• 金额: $ 49.57万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-05-01 至 2006-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6572686
• 关键词: behavioral /social science research tag; bioimaging /biomedical imaging; brain; bulimia nervosa; clinical research; cognitive behavior therapy; eating disorders; female; human subject; imaging /visualization /scanning; interview; opioid receptor; positron emission tomography; ultrasound blood flow measurement; women's health

DESCRIPTION (provided by applicant): The cause of bulimia nervosa is incompletely understood however animal and human studies have implicated the endogenous opioid system in feeding behavior. We hypothesize that there are both trait and state-related differences in the distribution and modulation of the opioidergic system that underlie the reinforcing quality inherent in this behavioral disorder. We propose to use positron emission tomography (PET)-scanning to measure mu-opiate receptors in patients with bulimia nervosa before and after treatment and in control women. Pilot data suggest a relationship between opioid receptors and the etiology or symptoms of bulimia. We propose to elucidate this relationship and to examine its change with treatment, specifically with normalization of eating behavior. The specific aims of this study are to: 1) Measure regional brain mu opioid receptors by PET in female patients with bulimia nervosa and matched normal controls. 2) Measure the change in regional mu opioid receptors by PET before and after cognitive behavioral therapy (CBT) of patients with bulimia nervosa It is anticipated that elucidation of the role of the endogenous opioid system in bulimia nervosa will not only help elucidate the etiology of this disorder, but also bring about new approaches to diagnosis, long-term risk assessment, and monitoring of treatment.

描述(由申请人提供)：神经性贪食症的原因尚不完全清楚，然而动物和人类研究表明，内源性阿片系统与进食行为有关。我们假设，在阿片能系统的分布和调节方面存在与特征和状态相关的差异，这些差异是这种行为障碍固有的强化性质的基础。我们建议使用正电子发射断层扫描(PET)扫描来检测神经性贪食症患者治疗前后和对照组妇女的阿片受体。试点数据表明，阿片受体与暴食症的病因或症状之间存在关系。我们建议阐明这种关系，并通过治疗，特别是饮食行为的正常化来检查它的变化。本研究的具体目的是：1)用正电子发射计算机断层扫描技术测定女性神经性贪食症患者和正常对照组的脑局部阿片受体。2)用正电子发射计算机断层扫描(PET)检测神经性贪食症患者认知行为治疗(CBT)前后局部MU阿片受体的变化，预计阐明内源性阿片系统在神经性贪食症中的作用不仅有助于阐明神经性贪食症的病因，而且将为诊断、长期风险评估和治疗监测提供新的途径。