Functional Neuroanatomical Deficits in ADHD Families

描述(由申请者提供)：尽管有过多的神经心理学 基于家庭的研究表明，注意力缺陷多动 障碍(ADHD)是一种基于神经生物学的疾病，研究试图 定义ADHD的神经生物学性质的人很少。如NIMH中所述 关于ADHD的共识发展会议，显然需要更多 基本上用基本的研究方法来定义ADHD。拟议的研究将 利用ADHD儿童多模式治疗研究(MTA)样本招募 30个多动症亲子二人组。ADHD二人组将由ADHD儿童和他们的 一致受影响的ADHD父母。还将招募15个正常的二元组 不符合ADHD诊断标准的患者。使用磁学技术的体积成像 所有二元体都将获得磁共振成像(MRI)。此外，所有的二元体 将进行一系列神经心理测试，而普通大脑 激活使用功能磁共振成像(FMRI)进行评估。多动症亲子二人组 还将参与一项重复的措施研究，检查功能 刺激性药物反应的神经解剖学改变。脑激活 将评估预先指定的感兴趣区域的体积和震级。 组间比较将评估结构和功能 ADHD与正常亲子二联体的神经解剖学差异。 组内分析将比较ADHD患者的功能激活变化 在安慰剂和有效药物条件下。此外，亲子关系 神经心理表现、神经解剖学和大脑的对应关系 将在两组二联体中检查激活情况。此应用程序是 将涉及五个站点的协作R01。参与者将是 从三个MTA网站招聘：纽约大学医学中心(DUMC) 州立精神病研究所和加州大学伯克利分校。成像将在以下时间执行 康奈尔大学威尔医学院DUMC的相应成像站点 斯坦福大学和斯坦福大学。

DESCRIPTION (provided by applicant): Despite a plethora of neuropsychological and family-based research suggesting that Attention Deficit Hyperactivity Disorder (ADHD) is a neurobiologically-based disorder, studies attempting to define the neurobiological nature of ADHD have been few. As stated in the NIMH Consensus Development Conference on ADHD, there is a clear need to more basically define ADHD using basic research techniques. The proposed study will utilize the Multimodal Treatment Study of ADHD children (MTA) sample to recruit 30 ADHD parent-child dyads. ADHD dyads will consist of ADHD children and their concordantly-affected ADHD parents. Fifteen normal dyads will also be recruited who do not meet ADHD diagnostic criteria. Volumetric images using Magnetic Resonance Imaging (MRI) will be acquired on all dyads. In addition, all dyads will perform a series of neuropsychological tests while generic brain activation is assessed using functional MRI (fMRI). ADHD parent-child dyads will also participate in a repeated measures study examining functional neuroanatomical change in response to stimulant medication. Brain activation volumes and magnitudes in pre-specified regions of interest will be assessed. Between-group comparisons will evaluate structural and functional neuroanatomical differences between ADHD and normal parent-child dyads. Within-group analyses will compare ADHD patients' functional activation changes across placebo and active medication conditions. In addition, parent-child correspondences in neuropsychological performance, neuroanatomy, and brain activation will be examined within the two groups of dyads. This application is a collaborative R01 that will involve five sites. Participants will be recruited from three MTA sites: University Medical Center (DUMC), New York State Psychiatric Institute, and UC Berkeley. Imaging will be performed at corresponding imaging sites at DUMC, Weill Medical College of Cornell University, and Stanford University respectively.