Exploiting insect tyrosine metabolism for vector control: laboratory and field verification

利用昆虫酪氨酸代谢进行病媒控制：实验室和现场验证

• 批准号: 2269494
• 金额: --
• 依托单位: Liverpool School of Tropical Medicine
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2269494
• 关键词: Exploiting; insect; tyrosine; metabolism; vector

The burden of vector-borne disease, residual malaria transmission and the threat of resistance to insecticide-based vector control all drive the current search for novel vector control tools. This research project will address the need for an effective and environmentally friendly compound for use, alongside current methods of vector control. An example of such compounds are inhibitors of insect tyrosine degradation, including nitisinone, which is FDA-approved and used for treating human metabolic diseases. The specific questions of this PhD project are: 1. What is the mosquitocidal effect of nitisinone, a tyrosine metabolism inhibitor, when fed to mosquitoes via blood meals and/or sugar meals? 2. What is the predicted efficacy of nitisinone as an endectocide (PK/PD modelling) and/or an ATSB? (ATSB modelling)3. How does nitisinone perform compared to other gold standards for mosquito control when used as endectocide and/or an ATSB? This project aims to answer these questions using first laboratory-reared mosquitoes and then wild populations, with the objective of validating and optimising predictive models that have been generated, using in-vitro laboratory data.

病媒传播疾病的负担、疟疾的残余传播以及对基于杀虫剂的病媒控制产生抗药性的威胁，都促使目前寻求新的病媒控制工具。该研究项目将解决对有效和环境友好的化合物的需求，以及目前的病媒控制方法。这样的化合物的实例是昆虫酪氨酸降解的抑制剂，包括尼替西酮，其是FDA批准的并且用于治疗人类代谢疾病。本博士项目的具体问题是：1。当通过血粉和/或糖粉喂给蚊子时，酪氨酸代谢抑制剂尼替西酮的灭蚊效果如何？2.尼替西农作为杀内寄生虫剂（PK/PD模型）和/或ATSB的预测疗效是什么？(ATSB建模）3.与其他用于蚊虫控制的金标准相比，尼替西酮在用作杀昆虫剂和/或ATSB时表现如何？该项目旨在首先使用实验室饲养的蚊子，然后使用野生种群来回答这些问题，目的是使用体外实验室数据验证和优化已生成的预测模型。