RACIAL DIFFERENCES IN PROSTATE CANCER TREATMENT OUTCOMES--YOUNG MEN

前列腺癌治疗结果的种族差异——年轻人

• 批准号: 6653353
• 负责人: PAUL A. GODLEY
• 金额: $ 8.37万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2003-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6653353
• 关键词: African American; caucasian American; clinical research; culture; health behavior; health care policy; health care referral /consultation; health care service availability; health care service utilization; human morbidity; human mortality; human subject; human therapy evaluation; interview; long term survivor; neoplasm /cancer diagnosis; neoplasm /cancer therapy; outcomes research; patient care management; prognosis; prostate neoplasms; prostate specific antigen; racial /ethnic difference; social support network; socioeconomics; training level

Prostate cancer poses significant burdens of mortality and morbidity on black men, greater than in while men, especially in the southeastern US. Prostate cancer in black men is diagnosed at a later state, with consequently a worse prognosis. This study will build on our previous studies on prostate cancer in elderly black men, and use similar methods to our study of rectal carcinoma. Our specific questions (controlling for potential confounders) are: 1) Do black men receive less aggressive treatment for localized prostate cancer than white men? 2) Do black men with prostate cancer have a history of less frequent screening with prostate specific antigen (PSA) and white men with prostate cancer? 3) Are knowledge, attitudes and beliefs regarding PSA screening and treatment different black and white men with prostate cancer? We will conduct a case-case study of 300 incident cancer among black men and 300 incident cases of prostate cancer among white men age 65 and older in a 33 county area of North Carolina. Cases will be identified from the North Carolina Central Cancer Registry. After obtaining permission from the patient's physician, we will obtain medical records and conduct a detailed telephone interview to assess demographics; income and poverty levels; education; level of social support; attitudes toward screening tests, especially cancer screening; access to health care; history of use of prostate and other screening tests compared with use of PSA as a diagnostic test; stage of cancer and types of treatments used. This study will determine: 1) whether initial treatment could account for these racial disparities in treatment outcomes, and 2) whether attitudes toward screening tests in general, and prostate cancer in particular, or other factors appear to explain these differences. This examination of the multiple possible factors for which race may serve as an indicator will substantially improve our understanding of racial disparities in prostate cancer, leading to targeted interventions.

前列腺癌对黑人男性的死亡率和发病率构成了重大负担，比白人男性更大，特别是在美国东南部。黑人男性前列腺癌的诊断较晚，因此预后较差。这项研究将建立在我们以前对老年黑人男性前列腺癌的研究基础上，并使用与我们对直肠癌研究相似的方法。我们的具体问题（控制潜在的混杂因素）是：1）黑人男性接受的局限性前列腺癌的积极治疗比白色男性少吗？2)患有前列腺癌的黑人男性和患有前列腺癌的白色男性是否有前列腺特异性抗原（PSA）筛查频率较低的历史？3)黑人和白色男性前列腺癌患者对PSA筛查和治疗的知识、态度和信念是否不同？我们将对北卡罗来纳州33个县地区65岁及以上的300例黑人男性癌症病例和300例白色男性前列腺癌病例进行一项案例研究。病例将从北卡罗来纳州中央癌症登记处确定。在获得患者医生的许可后，我们将获得医疗记录并进行详细的电话访谈，以评估人口统计学;收入和贫困水平;教育;社会支持水平;对筛查测试的态度，特别是癌症筛查;获得医疗保健;使用前列腺和其他筛查测试的历史与使用PSA作为诊断测试的历史进行比较;癌症的阶段和使用的治疗方法。这项研究将确定：1）初始治疗是否可以解释这些治疗结果的种族差异，2）对筛查测试的态度，特别是前列腺癌，或其他因素是否可以解释这些差异。这种对种族可能作为指标的多种可能因素的检查将大大提高我们对前列腺癌种族差异的理解，从而导致有针对性的干预措施。