Core C

核心C

• 批准号: 6748005
• 负责人: WILLIAM Robert GRECO
• 金额: $ 8.5万
• 依托单位: ROSWELL PARK CANCER INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-05-15 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6748005
• 关键词: biomedical facility; cancer information system; computer program /software; computer system design /evaluation; computer system hardware; data collection methodology /evaluation; data management; information dissemination; mathematical model; neoplasm /cancer photoradiation therapy; pharmacokinetics; statistics /biometry

The activities of the Biomathematics unit will be essential for maximizing the yield of useful information from the scientific/clinical projects in this Photodynamic Therapy Program. An objective, quantitative approach to basic and clinical research is especially relevant when the systems under study are complex and when program goals demand the integrated participation of several scientists. Although collaborations are primarily initiated by other researchers in the Program, the Biomathematics Unit, in its effort to identify useful quantitative techniques, may also initiate collaborations. After identifying useful, quantitative, biomathematical techniques, they are checked, corrected if necessary, extended if potentially fruitful, implemented into specific tools and used to facilitate a deeper understanding of complex photodynamic, pharmacokinetic and cellular kinetic systems. Laboratory and clinical scientists can obtain the use of biomathematical expertise, advice and use of custom and commercial computer software and hardware, and tutorials and advice of varying depth on biomathematical topics by communicating their need to the Biomathemats Unit. Collaborations can range from a five minute conversation to multiyear, multiproject programs. Specific aims include: 1. Mathematical models, usually empirical or semi-empirical, will be adapted from the literature, or created, as needed. Individual statistical analyses will be applied to data in specific studies. Experimental design advice will be provided. Routine standardized data analysis procedures will be implemented in specific labs. Results from routine use will be reviewed. 2. Specific individual databases will be set up for specific projects. Joint central databases will be set up where needed. Databases will be updated and adapted to changing requirements of specific projects. 3. Seminars on Biomathematics topics will be given. Tutorials on software and/or data analysis techniques and principles will be provided where needed. Results will be presented at scientific meetings. Results will be published in scientific j ournals. 4. Minor installations, improvements and repairs will be made to computer software/hardware systems.

生物数学单元的活动对于最大限度地从这个光动力治疗计划的科学/临床项目中获得有用信息至关重要。当所研究的系统比较复杂，且项目目标需要多名科学家的共同参与时，对基础和临床研究采取客观、定量的方法尤为重要。虽然合作主要是由该计划的其他研究人员发起的，但生物数学部门在努力确定有用的定量技术时，也可能发起合作。在确定了有用的、定量的、生物数学的技术之后，对它们进行检查，必要时进行纠正，如果可能有成果的话进行扩展，实现到特定的工具中，并用于促进对复杂的光动力学、药代动力学和细胞动力学系统的更深层次的理解。实验室和临床科学家可以获得生物数学专业知识的使用，建议和使用定制和商业计算机软件和硬件，以及通过与生物数学单元沟通他们的需求来获得生物数学主题的不同深度的教程和建议。合作的范围可以从五分钟的谈话到多年的、多项目的项目。具体目标包括：1。数学模型，通常是经验的或半经验的，将根据需要从文献中改编或创建。个别统计分析将应用于具体研究的数据。提供实验设计建议。