Core B

核心B

• 批准号: 6748004
• 负责人: WILLIAM R POTTER
• 金额: $ 11.28万
• 依托单位: ROSWELL PARK CANCER INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-05-15 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6748004
• 关键词: biomedical facility; chemical structure function; disease /disorder model; dosage; human subject; laboratory mouse; lasers; neoplasm /cancer pharmacology; neoplasm /cancer photoradiation therapy; nonvisual photosensitivity; optics; pharmacokinetics; photochemistry; photosensitizing agents; radiation therapy dosage

The overall role of the Optics and Dosimetry Core, is to provide support for the light delivery for PDT both in the clinic and in the laboratory. This includes the setup of the light delivery devices (lasers, fibers, beam splitters) for both clinical and laboratory photodynamic therapy. PDT in both the laboratory and the clinic requires proper dosimetry. To perform this function it is necessary to understand the dosinletry of PDT, The limited understanding of dosimetry as dependant on the interaction of light and a drug has been expanded through study' of the QSAR data on the pyropheophorbide hexyl ether series to include a sensitive target for PDT. As more specific targeting is designed into PDT drugs we intend to continue to study the dosimetry of PDT in an attempt to support and provide a testable fralnework in which to understand the results of the projects in overall study of structure activity relationships. Core personnel will perform laser maintenance, calibration and dosimetric measurements required by the clinical and laboratory research activities of the prqiects. The specific support role functions of the Core are: 1. Teclmical support for the clinical and sciemific lasers of the clinical and laboratory programs of the Program Project. 2. Measuremem ofphotobleaching during therapy. 3. Measurement of the total attenuation of tumor and normal tissue in patients undergoing PDT for the treatment of skin tumors, and the hemoglobin absorption spectra. 4. Study of the pharlnacokinetics of the compounds symhesized by Proiect I. 5 Refining the analytic framework of PDT targeting and dosimetry.

光学和剂量学核心的总体作用是为临床和实验室的PDT光输送提供支持。这包括用于临床和实验室光动力治疗的光传输设备（激光器，光纤，分束器）的设置。实验室和临床的PDT都需要适当的剂量测定。为了实现这一功能，有必要了解PDT的剂量学。通过对焦磷己基醚系列的QSAR数据的研究，扩大了对剂量学依赖于光与药物相互作用的有限理解，以包括PDT的敏感靶标。随着PDT药物更具体的靶向性设计，我们打算继续研究PDT的剂量学，试图支持并提供一个可测试的框架，以了解项目在结构活性关系整体研究中的结果。核心人员将执行激光