Core B

光学和剂量测定核心的总体作用是为临床和实验室中PDT的光输送提供支持。这包括用于临床和实验室光动力治疗的光传输设备（激光器、光纤、分束器）的设置。PDT在实验室和临床都需要适当的剂量测定。为了实现这一功能，有必要了解PDT的剂量学。通过研究焦脱镁叶绿酸己基醚系列的QSAR数据，将PDT的敏感靶点包括在内，扩大了对依赖于光和药物相互作用的剂量学的有限理解。随着PDT药物靶向性的提高，我们打算继续研究PDT的剂量学，以支持和提供一个可测试的框架，从而了解结构活性关系整体研究中项目的结果。核心人员将执行激光 受试者临床和实验室研究活动所需的维护、校准和剂量测定。 核心的具体支助作用职能是： 1.为计划项目的临床和实验室项目的临床和科学激光器提供技术支持。 2.治疗过程中光漂白的测量。 3.测量接受PDT治疗皮肤肿瘤的患者的肿瘤和正常组织的总衰减，以及血红蛋白吸收光谱。 4. Proiect I合成化合物的药理学研究。 5完善PDT靶向和剂量学的分析框架。

The overall role of the Optics and Dosimetry Core, is to provide support for the light delivery for PDT both in the clinic and in the laboratory. This includes the setup of the light delivery devices (lasers, fibers, beam splitters) for both clinical and laboratory photodynamic therapy. PDT in both the laboratory and the clinic requires proper dosimetry. To perform this function it is necessary to understand the dosinletry of PDT, The limited understanding of dosimetry as dependant on the interaction of light and a drug has been expanded through study' of the QSAR data on the pyropheophorbide hexyl ether series to include a sensitive target for PDT. As more specific targeting is designed into PDT drugs we intend to continue to study the dosimetry of PDT in an attempt to support and provide a testable fralnework in which to understand the results of the projects in overall study of structure activity relationships. Core personnel will perform laser maintenance, calibration and dosimetric measurements required by the clinical and laboratory research activities of the prqiects. The specific support role functions of the Core are: 1. Teclmical support for the clinical and sciemific lasers of the clinical and laboratory programs of the Program Project. 2. Measuremem ofphotobleaching during therapy. 3. Measurement of the total attenuation of tumor and normal tissue in patients undergoing PDT for the treatment of skin tumors, and the hemoglobin absorption spectra. 4. Study of the pharlnacokinetics of the compounds symhesized by Proiect I. 5 Refining the analytic framework of PDT targeting and dosimetry.