XRAY CRYSTALLOGRAPHIC STUDY OF CYTOPLASMIC DOMAIN OF SERINE CHEMORECEPTOR

这项研究将解决信号机制的问题， 分子水平通过确定X射线晶体结构的 E.大肠杆菌及其突变株 这显示了不同的信令行为。 结构测定 野生型丝氨酸受体的胞质结构域及其突变体， 不同的甲基化状态会给我们信号的信息， 通过膜受体传递和适应机制。

This research will address the question of signaling mechanisms at molecular level by determining the X-ray crystallographic structure of the cytoplasmic domain of a chemoreceptor from E. coli and its mutant which shows different signaling behavior. The structure determination of cytoplasmic domain of wild type serine receptor and its mutant with different methylation states will give us the information on signal transfer and adaptation mechanism through membrane receptor.