INTERFERON GAMMA & RECEPTOR COMPLEX & PROLACTIN & RECEPTOR COMPLEX CRYSTALS

我们已经获得了两种新的配体-受体复合物的晶体， 细胞因子受体超家族。 第一个复合体是绵羊的 催乳素结合两个催乳素受体胞外结构域。 的 这个综合体的第一个结构将是极大的兴趣， 了解人生长激素（hGH）的特异性特征， 催乳素及其受体。 它将提供失踪的 复合物hGH与其自身受体结合和 催乳素受体 第二个复合体是在一个inferon -g之间， 与其受体a链的单一拷贝复合的变体。 我们 我想评估催乳素/催乳素受体复合物的质量 晶体 我们有小但高度极化的晶体， 参见4.5 E“内部”衍射点。 我们需要评估他们的 具有极亮辐射的衍射质量。 我们也想 找出我们的干扰素-g/受体-a可以达到的分辨率 复杂的晶体

We have obtained crystals of two new ligand-receptor complexes of the cytokine receptor superfamily. The 1st complex is of ovine prolactin bound to two prolactin receptor extracellular domains. The first structure of this complex will be of great interest to understand the specificity profiles of human growth hormone (hGH) and prolactin and their receptors. It will provide the missing information between the complexes hGH bound to its own receptor and to the prolactin receptor. The 2nd complex is that between an inferon -g variant in complex with a single copy of its receptor a-chain. We want to assess the quality of our prolactin/prolactin receptor complex crystals. We have small but highly polarizable crystals, for which we see diffraction spots at 4.5 E "in-house". We need to assess their diffraction quality with extremely bright radiation. We also want to find out what resolution is achievable for our inferon -g/receptor-a complex crystals.