Applications of spider silk to regenerative medicine involving additive manufacture

蜘蛛丝在涉及增材制造的再生医学中的应用

• 批准号: 2270940
• 金额: --
• 依托单位: University of Nottingham
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2270940
• 关键词: Applications; spider; silk; regenerative; medicine

This multidisciplinary project will involve several interconnected work packages. The student will first identify suitable recombinant spider silks and compatible solvents for use as inks in the additive manufacturing of 3D structures for use in regenerative medicine or other healthcare applications. Having demonstrated the ability to print the unfunctionalized silk, the student will examine chemical and biological methods of adding functionalization to the silk either pre- or post printing and the new biomaterials will be assessed for their use as cell scaffolds. The final strand of the project will be to examine natural spider silks as printable substrates and to use bioinformatics to identify new silk genes that may expand on the properties of the currently used recombinant silks.

这一多学科项目将涉及几个相互关联的工作包。学生将首先确定合适的重组蜘蛛丝和相容溶剂，用作再生医学或其他医疗保健应用中使用的3D结构增材制造中的油墨。在证明了打印非功能化丝的能力后，学生将检查在打印前或打印后向丝添加功能化的化学和生物方法，并评估新生物材料作为细胞支架的用途。该项目的最后一部分将是检查作为可打印基质的天然蜘蛛丝，并使用生物信息学来识别新的丝基因，这些基因可能会扩展目前使用的重组丝的特性。