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CORE--FERMENTATION

核心--发酵

基本信息

批准号：
6605461
负责人：
KENNETH B TAYLOR
金额：
$ 19.59万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
起止时间：
2002-07-02 至 2003-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6605461
关键词：
Animalia Insecta biomedical equipment resource biomedical facility bioreactors microorganism tissue /cell culture

项目摘要

Description: (Applicant's Description) The overall goal of the Fermentation Shared Facility is to generate cells and biologic materials which will expedite research efforts of Cancer Center members. The Fermentation Shared Facility provides members of the Comprehensive Cancer Center with the capability to produce microbial, animal and insect cells and their products on a scale that would be uneconomic in the laboratory. The facility consists of space with equipment for large-scale cell growth, for cell disruption, for bioprocessing (purification) and for appropriate analytical measurements. The scale for cell growth ranges from eight to four hundred liters, whereas that for cell disruption ranges from one hundred milliliters to forty liters. In addition the facility makes available biomass of several stock strains of bacteria, one strain of animal cells and two proteins. The facility also makes available significant expertise in the production and purification of biological material. From October 1, 1997 to September 30, 1998, the facility provided 128 units of use by members of the Center for fermentation and bioprocessing. The facility was used by 14 principal investigators with 17 funded projects. Their use was instrumental in 29 publications. The usage of the Fermentation Shared Facility increased for the first 12 years of operation and now has apparently reached somewhat of a constant usage rate.

描述：（申请人的描述）发酵的总体目标共享设施用于生产细胞和生物材料，加快癌症中心成员的研究工作。发酵共享设施为综合癌症中心的成员提供生产微生物、动物和昆虫细胞及其产品的能力这种规模在实验室中是不经济的。该设施包括配备用于大规模细胞生长、细胞破碎、生物加工（纯化）和适当的分析测量。这细胞生长规模从八升到四百升不等，而细胞破碎的范围从一百毫升到四十升。在此外，该设施还提供几种库存菌株的生物量细菌、一种动物细胞菌株和两种蛋白质。该设施还提供生产和纯化方面的重要专业知识生物材料。从1997年10月1日到1998年9月30日，该设施提供了128个单位供发酵和生物加工中心成员使用。设施被 14 个主要研究人员用于 17 个资助项目。他们的用途是在 29 种出版物中发挥了重要作用。发酵共享的用途在运营的前 12 年里，设施有所增加，现在显然已达到了一定程度的恒定使用率。