MD Anderson Cancer Center SPORE in Head and Neck Cancer

MD 安德森癌症中心 SPORE 在头颈癌中的应用

• 批准号: 6531499
• 负责人: Waun Ki Hong
• 金额: $ 231.69万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6531499
• 关键词: clinical research; head /neck neoplasm

DESCRIPTION (provided by applicant): The University of Texas M. D. Anderson Cancer Center is proposing a Specialized Program of Research Excellence (SPORE) in head and neck cancer. The primary goal of this research program is to cultivate and facilitate innovative and significant translational research in the biologic, genetic and clinical aspects of early detection, prevention and treatment of head and neck cancer. These efforts will lead to changes in clinical practice that favorably impact mortality and morbidity of patients with cancer and decrease the incidence of head and neck cancer. The multidisciplinary group of distinguished investigators assembled for this research program will accomplish this goal through effective and collaborative integration of laboratory, epidemiologic and clinical investigations. Such activity will further our understanding of genetic susceptibility and the tumorigenic process in target tissue, leading to novel, molecularly-targeted strategies for the treatment and prevention of head and neck cancer. As outlined below, the program is designed with five research projects and three core resources, as well as programs for developmental research and career development. The research projects are designed to target specific areas important in head and neck cancer, as well as cancers at other disease sites. Project 1: Genetic Susceptibility Markers in Surrogate and Target Tissues Project 2: Targeting Angiogenesis for Therapy of Head and Neck Cancer Project 3: Targeting EGFR for Chemoprevention of Head and Neck Cancer Project 4: Targeting the p53 Pathway for Reversal of Oral Premalignancy Project 5: Targeting Induction of Apoptosis for Therapy of Head and Neck Cancer Core : Biostatistics and Data Management Core : Tissue Procurement and Pathology Developmental Research Program and Career Development Program Through this research program, our research team will make a significant impact on prevention and clinical care of patients with head and neck cancer. We will bring all of our resources to bear on this problem.

描述（由申请人提供）：德克萨斯大学MD安德森分校 癌症中心提出一项专门的卓越研究计划 (SPORE) 治疗头颈癌。该研究计划的主要目标是 培养和促进创新和重要的转化研究 在生物学、遗传学和临床方面进行早期检测、预防 以及头颈癌的治疗。这些努力将带来改变 对患者死亡率和发病率产生有利影响的临床实践 与癌症并降低头颈癌的发病率。这 为此聚集了由杰出研究人员组成的多学科小组 研究计划将通过有效和协作来实现这一目标 实验室、流行病学和临床调查的整合。这样的 活动将进一步加深我们对遗传易感性和 靶组织的致瘤过程，从而产生新型的分子靶向药物 治疗和预防头颈癌的策略。作为 概述如下，该计划设计有五个研究项目和三个 核心资源以及发展研究和职业计划 发展。研究项目旨在针对特定领域 对于头颈癌以及其他疾病部位的癌症很重要。 项目 1：替代组织和目标组织中的遗传易感性标记 项目2：靶向血管生成治疗头颈癌 项目3：靶向EGFR用于头颈癌的化学预防 项目 4：针对逆转口腔癌前病变的 p53 通路 项目5：头颈靶向诱导凋亡治疗 癌症 核心：生物统计学和数据管理 核心：组织采购和病理学 发展研究计划和职业发展计划 通过这个研究计划，我们的研究团队将取得重大进展 对头颈癌患者的预防和临床护理的影响。 我们将动用所有的资源来解决这个问题。