MD Anderson Cancer Center SPORE in Head and Neck Cancer

个人描述(申请人提供)：德克萨斯大学安德森分校 癌症中心正在提出一项专门的卓越研究计划 (孢子)在头颈部癌症中。这项研究计划的主要目标是 培养和促进创新和有意义的翻译研究 在生物学、遗传学和临床方面的早期发现、预防 以及头颈部癌症的治疗。这些努力将导致 有利于影响患者死亡率和发病率的临床实践 减少头颈部癌症的发病率。这个 为此聚集了多学科的杰出调查人员小组 研究计划将通过有效和协作的方式实现这一目标 实验室、流行病学和临床调查相结合。是这样的 活动将加深我们对遗传易感性和 靶组织中的肿瘤形成过程，导致新的、分子靶向的 头颈部癌症的治疗和预防策略。AS 该计划由五个研究项目和三个项目组成 核心资源，以及发展研究和职业计划 发展。这些研究项目是针对特定领域而设计的 在头颈癌以及其他疾病部位的癌症中很重要。 项目1：代孕组织和目标组织中的遗传易感标记 项目2：头颈癌的靶向血管生成治疗 项目3：以表皮生长因子受体为靶点用于头颈癌的化学预防 项目4：靶向p53通路逆转口腔癌前病变 项目5：靶向诱导细胞凋亡用于头颈部治疗 癌 核心：生物统计和数据管理 核心：组织采购和病理学 发展研究计划和职业发展计划 通过这项研究计划，我们的研究团队将取得重大进展 对头颈癌患者预防和临床护理的影响。 我们将动用我们所有的资源来解决这个问题。

DESCRIPTION (provided by applicant): The University of Texas M. D. Anderson Cancer Center is proposing a Specialized Program of Research Excellence (SPORE) in head and neck cancer. The primary goal of this research program is to cultivate and facilitate innovative and significant translational research in the biologic, genetic and clinical aspects of early detection, prevention and treatment of head and neck cancer. These efforts will lead to changes in clinical practice that favorably impact mortality and morbidity of patients with cancer and decrease the incidence of head and neck cancer. The multidisciplinary group of distinguished investigators assembled for this research program will accomplish this goal through effective and collaborative integration of laboratory, epidemiologic and clinical investigations. Such activity will further our understanding of genetic susceptibility and the tumorigenic process in target tissue, leading to novel, molecularly-targeted strategies for the treatment and prevention of head and neck cancer. As outlined below, the program is designed with five research projects and three core resources, as well as programs for developmental research and career development. The research projects are designed to target specific areas important in head and neck cancer, as well as cancers at other disease sites. Project 1: Genetic Susceptibility Markers in Surrogate and Target Tissues Project 2: Targeting Angiogenesis for Therapy of Head and Neck Cancer Project 3: Targeting EGFR for Chemoprevention of Head and Neck Cancer Project 4: Targeting the p53 Pathway for Reversal of Oral Premalignancy Project 5: Targeting Induction of Apoptosis for Therapy of Head and Neck Cancer Core : Biostatistics and Data Management Core : Tissue Procurement and Pathology Developmental Research Program and Career Development Program Through this research program, our research team will make a significant impact on prevention and clinical care of patients with head and neck cancer. We will bring all of our resources to bear on this problem.