Using Confinement and Surface Chemistry to Control Crystallisation

利用限制和表面化学来控制结晶

• 批准号: 2272650
• 金额: --
• 依托单位: University of Leeds
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2272650
• 关键词: Using; Confinement; Surface; Chemistry; Control

This project will investigate the effects of confinement and surface topography on crystal nucleation and growth with the goal of ultimately using these effects to control crystallisation. Crystallisation in the real world often occurs within small volumes rather than bulk solution, where thus can have significant effects on crystallisation from solution, controlling polymorph and orientation, and retarding crystallisation rates by orders of magnitude. Similarly, it is anecdotally well known that surface topographical features such as sharp cracks can significantly promote nucleation. In both cases, the origins of these effects are poorly understood. This project will investigate these processes. Systematic studies will be carried out on the effects of confinement on inorganic and organic crystals using environments including controlled pores glasses and nanotubes. A wide range of techniques including solid state NMR, transmission electron microscopy and X-ray and electron tomography will be employed. Coupled with the insight provided by the modelling groups, this work deliver an enhanced understanding of how confinement affects crystallisation, which will ultimately enable us to exploit confinement in order to control crystallisation. The project will also investigate crystallisation on substrates exhibiting natural cracks, where these topographical features appear to act as effective nucleation sites. Looking at natural substrates such as feldspars and synthetic substrates including oxidised PDMS, experiments will determine the features required to induce nucleation of a wide range of compounds.

本项目将研究限制和表面形貌对晶体成核和生长的影响，最终利用这些影响来控制结晶。在真实的世界中的结晶通常发生在小体积而不是本体溶液中，因此可以对从溶液中结晶、控制多晶型和取向以及将结晶速率延迟几个数量级具有显著影响。类似地，众所周知的是，表面形貌特征如尖锐裂纹可以显著促进成核。在这两种情况下，这些影响的起源都知之甚少。本项目将研究这些过程。系统的研究将进行约束对无机和有机晶体使用的环境，包括控制孔玻璃和纳米管的影响。广泛的技术，包括固态核磁共振，透射电子显微镜和X射线和电子断层扫描将采用。再加上建模小组提供的见解，这项工作提供了一个更好的了解如何限制影响结晶，这将最终使我们能够利用限制，以控制结晶。该项目还将研究显示自然裂缝的基板上的结晶，这些地形特征似乎是有效的成核位点。着眼于天然基板，如菱镁矿和合成基板，包括氧化PDMS，实验将确定所需的功能，以诱导成核的广泛的化合物。