TRAINING GRANT IN CVD GENETIC EPIDEMIOLOGY

（申请人？s摘要） 心血管疾病及其相关表型的遗传基础 定义不明确。分子和统计领域的进展 遗传学极大地提高了我们理解遗传病因学的能力， 复杂的疾病，比如心血管疾病几项CVD遗传流行病学研究 具有丰富的良好表征的基因型、环境和表型 数据可用。人类基因组计划将有人类的序列 到2003年完成的基因组DNA，目前有丰富的数据， 资源进行有关遗传和基因组贡献的分析， CVD。对科学家的需求很大， 各种类型的数据（遗传、环境和表型）。遗传 流行病学家，在流行病学方法，统计学和 迫切需要遗传学来扩大这一新兴领域的研究机会。 领域 这项为期五年的提案，如果获得批准，将提供3个博士前的培训 研究员和1个博士后研究员职位。对博士预科的需求 奖学金，根据最近申请博士学位。该部门的计划， 正在增加。此外，我们目前拥有优秀的博士预科和 博士后候选人谁将有资格获得奖学金，如果 提案得到资助。项目？的优良设施，大而多样 教师和广泛的研究机会提供了出色的培训 环境 明尼苏达大学的两到三年奖学金计划提供 优秀的培训机会，直接研究经验，遗传 流行病学与正式课程工作的强大课程相结合， 研讨会等妇女和少数民族的参与是一个高度优先事项， 奖学金培训。培训的独特性在于其承诺 教师和广度和深度的现有研究在家庭为基础的研究 在CVD中，以及人口，分子和 统计遗传学对合格的CVD遗传流行病学家的需求是 紧急，和培训科学家的研究事业在CVD遗传 流行病学将有助于进一步了解复杂的遗传 CVD的病因。(End摘要）

(Applicant?s Abstract) The genetic basis of cardiovascular diseases (CVD) and its related phenotypes is poorly defined. Advancements in the fields of molecular and statistical genetics have greatly enhanced our ability to understand the genetic etiology of complex diseases, like CVD. Several CVD genetic epidemiological studies have a wealth of well-characterized genotypic, environmental, and phenotypic data available. The Human Genome Project will have the sequence of human genomic DNA completed by 2003, an currently has abundance of data and resources to conduct analyses related to genetic and genomic contributions to CVD. There is a great demand for scientists that successfully integrate various types of data (genetic, environmental, and phenotypic). Genetic epidemiologist, rigorously trained in epidemiologic methods, statistics, and genetics are urgently needed to expand research opportunities in this emerging field. This five-year proposal, if awarded, will provide training for 3 pre-doctoral fellows and 1 post-doctoral fellowship positions. The demand for pre-doctoral fellowships, based on recent applicants to the Ph.D. program in the Division, is increasing. In addition, we currently have excellent pre-doctoral and post-doctoral candidates who would be eligible for a fellowship if the proposal is funded. The Program?s excellent facilities, large and diverse faculty, and broad research opportunities offer an outstanding training environment. The University of Minnesota two to three year fellowship program offers outstanding training opportunities in direct research experience in genetic epidemiology combined with a strong curriculum of formal course work and seminars. The participation of women and minorities is a high priority for fellowship training. The uniqueness of the training is the commitment of its faculty and the breadth and depth of existing research in family-based studies in CVD, and the combination of coursework in population, molecular, and statistical genetics. The need for qualified CVD genetic epidemiologists is urgent, and the training of scientists for research careers in CVD genetic epidemiology will help to further understanding of the complex genetic etiology of CVD. (End of Abstract)