Anti-Inflamatory Coatings for Biomaterials

生物材料抗炎涂层

• 批准号: 6596744
• 负责人: JOHN A FRANGOS
• 金额: $ 88.12万
• 依托单位: LA JOLLA BIOENGINEERING INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-15 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6596744
• 关键词: antioxidants; biomaterial development /preparation; biotechnology; ceramics; inflammation; surface coating

DESCRIPTION (provided by the applicant): The prolonged inflammatory response to an implant is one of the primary causes for the failure to integrate into tissue. The two sources of inflammation common to almost all implants are the foreign body response and the relative movement of the implant with the surrounding tissue. Based on evidence in the literature and from our research team, the inflammatory response is mediated by the reactive oxygen species generated by macrophages, leukocytes, and the surrounding connective tissue. Based on our findings, it is evident that titanium dioxide and similar ceramics, even when present as surface coatings of polymeric biomaterials, have the ability to breakdown reactive oxygen species that have been identified as mediators of the inflammatory response. The goal of this Program is to develop applications for our catalytic antioxidant ceramic technology in the biomaterials and medical device industry. This Program, led by UCSD, consists of five projects with ten academic and industrial partners. Project 1 will investigate the basic mechanisms of action of metal oxides in the catalytic breakdown of reactive oxygen species. By understanding the fundamental reaction kinetics of the catalytic action of titanium dioxide, catalysts of greater efficiency may be discovered. Project 2 will fabricate and characterize materials for the other four projects. This project involves partners from Lawrence Livermore National Labs, Drexel Univ., and UCSD. Project 3 will test the in vivo inflammatory and foreign body response in two in vivo models; a standard rat model and the hamster window model. This project provides a core service to the other projects, but also investigates fundamental mechanisms of the inflammatory response to biomaterials. Project 4 will determine if the catalytic antioxidant ceramic technology is able to mitigate implant-tissue strain-induced inflammation. It will also investigate basic mechanisms of strain-induced inflammation. Project 5 is the interface with the medical device industry. Four Industrial Partners have been chosen to develop to apply the technology to four different biomaterial needs: Biosensor membranes for inplantable glucose sensors (GlySens) and biodegradable polymers for tissue engineering (Advanced Tissue Sciences) with reduced foreign body response; wound dressing material with anti-inflammatory properties (3M); and. dental materials with improved soft tissue integration (Nobel BioCare). By the first year, we will have elucidated the catalytic mechanisms of action of TiO,, established the ceramic coating technologies, characterized the inflammation response in the hamster model, and fabricated and tested dental coatings. Our overall objective is to provide the proof-of-principle to our industrial partners, which will encourage them to participate in more specific product development in the second phase (years 6-10) of the BRP.

描述（由申请人提供）：持续的炎症反应 植入物是不能整合到 组织.几乎所有植入物常见的两种炎症来源是： 异物反应和植入物与植入物的相对运动 周围组织根据文献中的证据和我们的研究 研究小组指出，炎症反应是由活性氧介导的， 由巨噬细胞、白细胞和周围结缔组织产生。 根据我们的发现，很明显，二氧化钛和类似物 陶瓷，即使作为聚合物生物材料的表面涂层存在， 分解活性氧物质的能力， 炎症反应的介质。该计划的目标是发展 我们的催化抗氧化陶瓷技术在 生物材料和医疗器械行业。该计划由UCSD领导，包括 与十个学术和工业合作伙伴的五个项目。项目1将 研究金属氧化物在催化反应中的基本作用机理。 分解活性氧。通过理解基本反应 二氧化钛的催化作用的动力学，催化剂的更大 可以发现效率。项目2将制作和表征 其他四个项目的材料。该项目的合作伙伴来自 劳伦斯利弗莫尔国家实验室，德雷克塞尔大学，UCSD的。 项目3将测试体内炎症和异物反应在两个 体内模型;标准大鼠模型和仓鼠窗口模型。这个项目 为其他项目提供核心服务，但也调查 生物材料炎症反应的基本机制。项目4 将决定催化抗氧化陶瓷技术是否能够 减轻植入物组织应变诱导的炎症。它还将调查 应变诱导炎症的基本机制。项目5是接口 与医疗器械行业。四个工业合作伙伴已被选中， 开发应用于四种不同生物材料需求的技术：生物传感器 用于植入式葡萄糖传感器（GlySens）和可生物降解聚合物的膜 用于组织工程（Advanced Tissue Sciences），减少异物 反应;具有抗炎特性的伤口敷料材料（3 M）;以及。 改善软组织整合的牙科材料（Nobel BioCare）。由 第一年，我们将阐明二氧化钛的催化作用机制， 建立了陶瓷涂层技术， 仓鼠模型中的反应，并制造和测试牙科涂料。我们 总体目标是为我们的工业提供原理证明 这将鼓励他们参与更具体的产品 在“两年期重建计划”第二阶段（第6-10年）的发展。