Organocatalytic Alcohol Activation

有机催化醇活化

• 批准号: 2274004
• 金额: --
• 依托单位: University of Nottingham
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2274004
• 关键词: Organocatalytic; Alcohol; Activation

This project involves the design, synthesis and development of novel phosphine oxide catalysts and their application in the activation of alcohols and other hydroxyl-containing functional groups such as carboxylic and sulfonic acids. Potential areas of reaction development will include new carbon-nitrogen and carbon-carbon bond-forming processes. In a second strand we will also investigate catalysts and Bronsted acid combinations that are suitable for the elimination of alcohols to afford alkenes. The latter topic will require further catalyst optimisation and this will be aided by QM calculations which we will use to explore the elementary steps of the catalytic cycle and the product-determining step in particular.

本项目涉及新型氧化膦催化剂的设计、合成和开发及其在醇类和其他含羟基官能团（如羧酸和磺酸）活化中的应用。反应发展的潜在领域将包括新的碳氮和碳碳成键工艺。在第二链中，我们还将研究适合于消除醇以产生烯烃的催化剂和Bronsted酸组合。后一个主题将需要进一步的催化剂优化，这将借助于QM计算，我们将用它来探索催化循环的基本步骤，特别是产物决定步骤。