STANFORD ALZHEIMER'S DISEASE CORE CENTER

本申请反映了斯坦福大学对阿尔茨海默病（AD）研究的持续承诺。自13年前国家精神卫生研究所（NIMH）老年人精神病理学研究计划成立以来，我们有一个专注于AD研究的NIMH中心。类似于AIA的“阿尔茨海默病核心中心（ADCC）”，我们NIMH中心的结构专注于AD的研究。与NIA的阿尔茨海默病核心中心（ADCC）类似，NIMH中心的结构一直是一个“授权或核心中心”，旨在使用“核心资源”促进独立资助的AD研究的发展。我们认为我们在这奋进的努力是成功的，在斯坦福大学使用该中心的核心制作了资助的AD项目。我们未来的计划是继续沿着这条轨道作为一个ADCC，因为我们的中心的目标和结构与NIA计划的任务比与新的NIMH计划更一致，新的NIMH计划将不再支持“核心中心”。我们中心的主要重点是研究AD的异质性方面。在当前的应用中，我们已经扩大了我们提出的ADCC的重点，以促进三个主要领域的研究：病因学;疾病进展;以及AD中相关行为症状的病理生理学。这项工作将与该大学在基础神经科学和遗传学，神经成像和睡眠/时间生物学方面的主要研究项目紧密结合。我们的期望是，我们不仅将促进这三个领域的研究，而且，由于我们的跨学科经验，我们将促进研究工作，桥梁学科和增加思想的交叉施肥。我们认为，这种多因素和跨学科的方法可能最好地解决当前AD研究的复杂问题。

This application reflects the continuing commitment of Stanford University to the study of Alzheimer's Disease (AD). Since the inception of the National Institute of Mental Health (NIMH) program for the Study of Psychopathology in the Elderly over 13 years ago, we have had an NIMH Center focusing on the study of AD. Similar to the AIA "Alzheimer's Disease Core Center (ADCC)," the structure of our NIMH Center focusing on the study of AD. Similar to the NIA "Alzheimer's Disease Core Centers (ADCC), the structure of NIMH Center has been that of an "enabling or core center" designed to use "core resources" to facilitate the development of independently funded research on AD. We feel that we been successful in this endeavor, producing funded AD projects at Stanford using the Center's core. Our plan for the future is to continue along this track as an ADCC because the objectives and structure of our Center our Center are more consistent with the mandate of the NIA program than with new NIMH programs that will no long support "core centers" Given our log history as an enabling center with established cores, we feel that we are ideally suited to accomplish this transition. The primary focus of our Center has been the study of aspects for the heterogeneity of AD. In the current application we have expanded the focus of our proposed ADCC to facilitate research in three major areas: etiology; progression of disease; and pathophysiology of associated behavioral symptoms in AD. This work will be closely integrated with major research programs at the University in basic neurosciences and genetics, neuroimaging, and sleep/chronobiology. Our expectation is that we will not only facilitate research in these three individual areas but also, because of our interdisciplinary experience, we will foster research efforts that bridge disciplines and increase cross-fertilization of ideas. We feel that this multi-factorial and interdisciplinary approach may best address complex questions current to AD research.