PHOTORECEPTOR FUNCTION IN RETINOPATHY OF PREMATURITY

描述(申请人的描述)：光感受器的新证据 活动性脉管期消退前后受累情况 早产儿视网膜病变(ROP)引出了该项目的主要假设： 光感受器功能缺陷越大，急性 阶段ROP。婴儿(10周岁入学)和儿童(8-12岁入学) 年)按ROP的严重程度分类(无、轻度、中度、重度) 光感受器的视网膜电信号和心理物理研究 功能。在所有受试者中，视杆细胞激活的参数 光转导和暗适应杆状阈值将在 黄斑旁和周边视网膜。将分析杆件响应参数，以 与ROP类别有显著差异。POST中显示的视网膜机制 接受者反应，以及接受者与后接受者之间的关系 功能，也将进行分析。高度屈光不正经常出现在ROP中 在光感受器成熟的那几年发育。在此项目中关于 视网膜机制的第二个假说是：感光器越大 功能障碍，屈光不正越大。所有受试者都会有 测量睫状肌麻痹患者的屈光度和视力。要评估 发展视网膜突起和用于因果关系的等效球， 视杆阈值、视力和屈光不正随年龄变化的纵向研究 课程为期10周，为期3年。这些课程的参数，以及 其他视网膜研究中获得的视网膜反应参数 函数，将用来检验第二个假设。在孩子们身上，其他 光感受器功能包括使杆状光传导失活， 激活视锥细胞光传导和视杆增量阈值函数 将会被调查。所获得的参数将用于进一步的测试 主要假设和次要假设，并在受试者内部评估 视杆与视锥的相对参与，激活与失活，以及 接受者机制与接受者后机制。这个项目，完全基于一个 ROP的新视角，不仅会带来更多关于 ROP中的视网膜和视觉功能，也是对基础知识的新认识 ROP疾病进程。

DESCRIPTION (Applicant's Description): New evidence for photoreceptor involvement before and after resolution of the active, vascular phase of retinopathy of prematurity (ROP) leads to the main hypothesis of this project: the greater the deficit in photoreceptor function the more severe the acute phase ROP. Infants (enrolled at age 10 wks) and children (enrolled at age 8-12 yrs) categorized by severity of ROP (None, Mild Moderate, Severe) will have electroretinographic (ERG) and psychophysical investigations of photoreceptor function. In all subjects, the parameters of the activation of rod phototransduction, and dark-adapted rod thresholds will be measured in parafoveal and peripheral retina. Rod response parameters will be analyzed for significant variation with ROP category. Retinal mechanisms represented in post receptoral responses, and the relationship of receptoral to post-receptoral functions, will also be analyzed. High refractive errors in ROP frequently develop during the years when photoreceptors mature. In this project about retinal mechanisms, the secondary hypothesis is: the greater the photoreceptor dysfunction, the greater the refractive error. All subjects will have cycloplegic refractions, as well as acuities, measured. To evaluate the developing retinal processes and spherical equivalent for causative relations, a longitudinal study of rod thresholds, acuity and refractive error between age 10 wks and 3 yrs will be conducted. The parameters of these courses, as well as the retinal response parameters obtained in the other studies of retinal function, will be used to test the secondary hypothesis. In the children, other photoreceptor functions including deactivation of rod phototransduction, activation of cone phototransduction, and rod increment threshold functions will be investigated. The parameters obtained will be used in further tests of the main and secondary hypotheses, and for within subject evaluation of relative involvement of rods vs. cones, activation vs. deactivation, and receptoral vs. post-receptoral mechanisms. This project, based on an entirely new perspective of ROP, will lead not only to much more information about retinal and visual function in ROP, but also to new knowledge about fundamental ROP disease processes.