ERP Studies of Dual Processes in Recognition Memory

识别记忆双过程的ERP研究

• 批准号: 6690027
• 负责人: TIMOTHY E Curran
• 金额: $ 29.07万
• 依托单位: UNIVERSITY OF COLORADO
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-01-01 至 2006-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6690027
• 关键词: adolescence (12-20); behavioral /social science research tag; brain electrical activity; clinical research; evoked potentials; human subject; memory; neural information processing; performance; university student; young adult human (21-34)

DESCRIPTION (provided by applicant): The purpose of the proposed research is to understand the neurocognitive processes that underlie human recognition memory. Recognition is supported by processes that are sensitive to the general familiarity of stimuli as well as by processes enabling the recollection of specific information. Behavioral research suggests that these processes can be dissociated by manipulating variables that differentially affect recollection and familiarity, but the characteristics of the underlying brain processes have yet to be reliably differentiated. Based on preliminary results, the proposed research investigates the hypothesis that recollection and familiarity can be differentiated with event-related brain potentials (ERPs). Early (300-500 ms) frontal ERP effects are modulated by stimulus familiarity, whereas later (400-800 ms) parietal ERP effects are related to recollection. The general aim of the proposed research is to better specify the relationship between the hypothesized ERP familiarity and recollection effects, contemporary theories of familiarity and recollection, and behavioral recognition memory performance. The first specific aim is to delineate the temporal correspondence between the hypothesized ERP familiarity and recollection effects and behavioral recognition memory performance. The second specific aim is to electrophysiologically replicate several behavioral dissociations between recollection and familiarity that have been previously reported. The third specific aim is to use ERPs to examine empirical phenomena that are central to current cognitive theorizing about recognition memory. The present research will advance our understanding of the processes that underlie human memory at both the cognitive and neural level. Our understanding of the brain mechanisms of memory will be advanced by characterizing the timing and anatomical separability of these processes. Our understanding of the cognitive processes of recollection and familiarity will be enhanced by establishing measures of brain electrical activity that reliably differentiate between these processes, by manipulating psychological variables known to affect recognition, and by observing how these variables differentially affect the electrophysiological measures of recollection and familiarity. Future studies can apply these methods to the investigation of memory impairments associated with normal aging, psychiatric disorders, and neurological damage.

描述(申请人提供)：建议研究的目的是 了解构成人类识别记忆基础的神经认知过程。 识别是由对一般情况敏感的过程支持的 对刺激的熟悉程度以及能够回忆起 具体信息。行为研究表明，这些过程可以是 通过操纵以不同方式影响回忆的变量而分离 和熟悉性，但潜在的大脑过程的特征 还没有得到可靠的区分。根据初步结果，拟议的 一项研究调查了记忆和熟悉可以是 与事件相关脑电位(ERPs)相区别。早期(300-500毫秒) 额叶ERP效应受刺激熟悉度的影响，而后者受刺激熟悉度的影响 (400-800ms)顶叶ERP效应与回忆有关。总的目标是 建议的研究的目的是更好地说明 假设的事件相关电位熟悉度和回忆效应，当代理论 熟悉度和回忆，以及行为识别记忆表现。 第一个具体目标是描绘出 假设事件相关电位熟悉度和回忆效应与行为 识别记忆性能。第二个具体目标是 在电生理学上复制了几种行为分离 回忆和熟悉，这是以前报道过的。第三 具体目的是使用事件相关电位来检查对以下问题至关重要的经验现象 目前关于认知记忆的认知理论。目前的研究 将促进我们对构成人类记忆基础的过程的理解 无论是认知层面还是神经层面。我们对大脑机制的理解 将通过表征时间和解剖学特征来推进记忆 这些过程的可分性。我们对认知过程的理解 将通过建立以下措施来提高回忆和熟悉程度 可靠地区分这些过程的脑电活动， 通过操纵已知的影响认知的心理变量，以及通过 观察这些变量如何不同地影响电生理 记忆和熟悉度的衡量标准。未来的研究可以应用这些 与正常相关的记忆损害的研究方法 衰老、精神障碍和神经损伤。