Developing the next generation of Collagen Membranes using Electrophoretic Deposition

使用电泳沉积开发下一代胶原膜

• 批准号: 2277385
• 金额: --
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2277385
• 关键词: Developing; next; generation; Collagen; Membranes

A new collagen membrane technology has been developed which has the potential to allow for a range of benefits, including the ability to make much larger collagen membranes than those currently available, where membranes can be made to any desired thickness and adopt any desired shape. The membranes are resistant to suture pull-out and can sustain live cells for regenerative applications.Conventional membrane fabrication methods use decellularised animal tissue which limits their size, requiring surgeons to use multiple membranes and preventing their use in larger area wounds such as burns or diabetic ulcers. Additionally, the decellularisation process can damage the structure of the membrane, or fail to remove all traces of the animal, leading to inflammation and rejection. The new technology uses a modified electrophoretic deposition technique to allow for rapid fabrication and precise control over a range of important membrane parameters including the size, thickness and shape. This is achieved by manipulating the inherently charged nature of biomolecules in suspension using electric fields. This technique can be applied to fabricate a wide variety of membranes tailored towards specific clinical needs and can create complex and targeted products. This project aims to expand on this research and develop the new collagen membrane technology with a wide range of applications.

已经开发了一种新的胶原蛋白膜技术，其具有允许一系列益处的潜力，包括制造比目前可用的胶原蛋白膜大得多的胶原蛋白膜的能力，其中膜可以被制造成任何期望的厚度并采用任何期望的形状。传统的膜制造方法使用脱细胞动物组织，这限制了它们的尺寸，需要外科医生使用多个膜，并防止它们用于更大面积的伤口，如烧伤或糖尿病溃疡。此外，去细胞化过程可能会破坏膜的结构，或无法去除动物的所有痕迹，导致炎症和排斥反应。这项新技术使用改进的电泳沉积技术，可以快速制造和精确控制一系列重要的膜参数，包括尺寸，厚度和形状。这是通过使用电场操纵悬浮液中生物分子的固有带电性质来实现的。该技术可用于制造针对特定临床需求定制的各种膜，并可制造复杂和有针对性的产品。本项目旨在扩大这项研究，开发具有广泛应用的新型胶原膜技术。