CTLA-4 Blockade to Stimulate Allogeneic Graft vs tumor

CTLA-4 阻断刺激同种异体移植物抗肿瘤

• 批准号: 6793733
• 负责人: EDWARD David BALL
• 金额: $ 40.5万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-30 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6793733
• 关键词: CD28 molecule; bone marrow transplantation; clinical research; clinical trials; cooperative study; disease /disorder prevention /control; hematopoietic tissue transplantation; human subject; human therapy evaluation; infection; leukocyte activation /transformation; patient oriented research; stem cell transplantation

This project is part of a Blood and Marrow Transplant Clinical Research Network which is conducting multicenter clinical trials in hematopoietic stem cell transplantation. The purpose of the network is to promote the efficient comparison of novel treatment methods and management strategies of potential benefit for children and adults undergoing blood or marrow transplantation. Studies under development include a comparison of blood versus marrow stem cell transplantation. Studies under development include a comparison of blood versus marrow stem cell transplantation after marrow ablation, the development of non-myeloablative transplant regimens, and the best ways to avoid infections in transplant patients.

该项目是血液和骨髓移植临床研究的一部分 该网络正在进行造血多中心临床试验， 干细胞移植 该网络的目的是促进 新的治疗方法和管理策略的有效比较 对接受血液或骨髓移植的儿童和成人 移植 正在进行的研究包括比较血液 与骨髓干细胞移植相比。 正在进行的研究包括 骨髓移植后造血干细胞移植与骨髓干细胞移植的比较 消融，非清髓性移植方案的开发，以及 避免移植患者感染的最佳方法。