GENETICS OF CORONARY ARTERY DISEASE IN ALASKAN NATIVES

阿拉斯加原住民冠状动脉疾病的遗传学

• 批准号: 6796417
• 负责人: Barbara v Howard
• 金额: $ 65.29万
• 依托单位: MEDSTAR HEALTH RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-21 至 2005-09-26
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6796417
• 关键词: Alaskan Native American; Chlamydiaceae; atherosclerosis; atherosclerotic plaque; bacteria infection mechanism; cardiovascular disorder epidemiology; carotid artery; clinical research; cooperative study; coronary disorder; cytomegalovirus; disease /disorder proneness /risk; electrocardiography; family genetics; gene mutation; genetic markers; genotype; human subject; hypertension; interview; linkage mapping; obesity; phenotype; ventricular hypertrophy; virus infection mechanism

This application is a working partnership between the Native-owned, non-profit corporation that manages the health care of the Native Alaskans of the Norton Sound and certain Strong Heart Study (SHS) investigators. The Norton Sound Health Corporation, a subcontractor to the Indian Health Service, provides medical care for the approximately 8,000 Native Alaskans living along the shores of the Bering Straits. The investigators bring many years of successful collaboration and individual experience in the epidemiology and genetics of minority health. There are many compelling reasons to study heart disease in the Native Alaskans. These Eskimos villages are remote and isolated. The traditional lifestyle is being eroded by mechanization and a westernized diet. There has been relatively little outside genetic influence and they are, like the American Indians of the lower 48 states, beginning to show a marked acceleration in the prevalence of atherosclerosis and coronary artery disease. The specific aims of this proposal are to carefully document CVD and CVD risk factors among 1200 Native Alaskans who are members of approximately 40 families. We will use standardized methodologies that will allow comparison with other populations. This will be a family- based, cross-sectionally study. Recognized and emerging risk factors, and prevalent CVD will be documented in each individual through a standardized interview, physical exam, laboratory measurements, carotid ultrasound, ECG and a review of centralized medical records. We will assay contemporary samples and serum specimens stored at the Anchorage CDC (from many participants) antedating this study (10-20 years ago) for specific markers of inflammation and serologic responses. Through a ten-centimorgan map, we will attempt to find specific genes that related to CVD. This will be the first project to identify and map genes that contribute to risk of CVD in this unique and understudied population.

该应用程序是一个本地拥有的非营利公司之间的工作伙伴关系，该公司管理诺顿湾的阿拉斯加土著人的医疗保健和某些强心研究（SHS）调查人员。诺顿海峡保健公司是印第安人保健服务的分包商，为居住在白令海峡沿着的大约8 000名阿拉斯加土著人提供医疗服务。研究人员带来了多年的成功合作和个人经验的流行病学和遗传学的少数民族健康。有许多令人信服的理由来研究阿拉斯加原住民的心脏病。这些爱斯基摩人的村庄都很偏僻。传统的生活方式正在被机械化和西化的饮食所侵蚀。外界遗传因素的影响相对较小，他们和美国48个州的印第安人一样，开始显示出动脉粥样硬化和冠状动脉疾病的患病率明显加快。该提案的具体目标是仔细记录来自大约40个家庭的1200名阿拉斯加原住民的心血管疾病和心血管疾病风险因素。我们将使用标准化的方法，以便与其他人群进行比较。这将是一项以家庭为基础的横断面研究。将通过标准化访谈、体格检查、实验室测量、颈动脉超声、ECG和集中病历审查，记录每个个体的公认和新出现的风险因素以及流行的CVD。我们将分析储存在安克雷奇CDC的当代样本和血清标本（来自许多参与者），这些样本和血清标本早于本研究（10-20年前）的炎症和血清学反应的特异性标志物。通过10 centimorgan图，我们将试图找到与CVD相关的特定基因。这将是第一个在这个独特和未充分研究的人群中识别和绘制导致CVD风险的基因的项目。

项目成果

Fatty acids linked to cardiovascular mortality are associated with risk factors.

• DOI: 10.3402/ijch.v74.28055
• 发表时间: 2015
• 期刊: International journal of circumpolar health
• 影响因子: 1.3
• 作者: Ebbesson SO;Voruganti VS;Higgins PB;Fabsitz RR;Ebbesson LO;Laston S;Harris WS;Kennish J;Umans BD;Wang H;Devereux RB;Okin PM;Weissman NJ;MacCluer JW;Umans JG;Howard BV
• 通讯作者: Howard BV