GENETICS OF CORONARY ARTERY DISEASE IN ALASKAN NATIVES

阿拉斯加原住民冠状动脉疾病的遗传学

• 批准号: 6796417
• 负责人: Barbara v Howard
• 金额: $ 65.29万
• 依托单位: MEDSTAR HEALTH RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-21 至 2005-09-26
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6796417
• 关键词: Alaskan Native American; Chlamydiaceae; atherosclerosis; atherosclerotic plaque; bacteria infection mechanism; cardiovascular disorder epidemiology; carotid artery; clinical research; cooperative study; coronary disorder; cytomegalovirus; disease /disorder proneness /risk; electrocardiography; family genetics; gene mutation; genetic markers; genotype; human subject; hypertension; interview; linkage mapping; obesity; phenotype; ventricular hypertrophy; virus infection mechanism

This application is a working partnership between the Native-owned, non-profit corporation that manages the health care of the Native Alaskans of the Norton Sound and certain Strong Heart Study (SHS) investigators. The Norton Sound Health Corporation, a subcontractor to the Indian Health Service, provides medical care for the approximately 8,000 Native Alaskans living along the shores of the Bering Straits. The investigators bring many years of successful collaboration and individual experience in the epidemiology and genetics of minority health. There are many compelling reasons to study heart disease in the Native Alaskans. These Eskimos villages are remote and isolated. The traditional lifestyle is being eroded by mechanization and a westernized diet. There has been relatively little outside genetic influence and they are, like the American Indians of the lower 48 states, beginning to show a marked acceleration in the prevalence of atherosclerosis and coronary artery disease. The specific aims of this proposal are to carefully document CVD and CVD risk factors among 1200 Native Alaskans who are members of approximately 40 families. We will use standardized methodologies that will allow comparison with other populations. This will be a family- based, cross-sectionally study. Recognized and emerging risk factors, and prevalent CVD will be documented in each individual through a standardized interview, physical exam, laboratory measurements, carotid ultrasound, ECG and a review of centralized medical records. We will assay contemporary samples and serum specimens stored at the Anchorage CDC (from many participants) antedating this study (10-20 years ago) for specific markers of inflammation and serologic responses. Through a ten-centimorgan map, we will attempt to find specific genes that related to CVD. This will be the first project to identify and map genes that contribute to risk of CVD in this unique and understudied population.

该应用程序是管理诺顿声音的本地阿拉斯加人的医疗保健与某些强大的心脏研究（SHS）研究人员之间的卫生保健之间的工作合作伙伴关系。印度卫生服务部的分包商诺顿桑德健康公司（Norton Sound Health Corporation）为居住在白令海峡海岸的大约8,000名本地阿拉斯加人提供医疗服务。调查人员在少数族裔健康的流行病学和遗传学方面具有多年的成功合作和个人经验。在阿拉斯加原住民中学习心脏病有很多令人信服的理由。这些爱斯基摩人村庄遥不可及。传统的生活方式正在被机械化和西化饮食侵蚀。外部遗传影响相对较少，就像下48个州的美国印第安人一样，在动脉粥样硬化和冠状动脉疾病的患病率方面开始表现出明显的加速度。该提案的具体目的是仔细记录约有40个家庭成员的1200名本地阿拉斯加人的CVD和CVD风险因素。我们将使用标准化方法，以允许与其他人群进行比较。这将是基于家庭的横截面研究。公认和新兴的危险因素以及普遍的CVD将通过标准化的访谈，体格检查，实验室测量，颈动脉超声，ECG和集中式医疗记录审查来记录每个人。我们将分析存储在锚定CDC（来自许多参与者）的当代样品和血清标本（10 - 20年前），以抗炎症和血清学反应的特定标记。通过十个中心地图，我们将尝试找到与CVD相关的特定基因。这将是第一个识别和映射在这个独特而研究的人群中有助于CVD风险的项目。

项目成果

Fatty acids linked to cardiovascular mortality are associated with risk factors.

• DOI: 10.3402/ijch.v74.28055
• 发表时间: 2015
• 期刊: International journal of circumpolar health
• 影响因子: 1.3
• 作者: Ebbesson SO;Voruganti VS;Higgins PB;Fabsitz RR;Ebbesson LO;Laston S;Harris WS;Kennish J;Umans BD;Wang H;Devereux RB;Okin PM;Weissman NJ;MacCluer JW;Umans JG;Howard BV
• 通讯作者: Howard BV