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Vestibular Responses of Rostral Fastigial Neurons

头端顶神经元的前庭反应

基本信息

批准号：
6739497
负责人：
Aasef G Shaikh
金额：
$ 4.99万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-09-01 至 2004-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6739497
关键词：
Macaca mulatta cell population study cerebellar nuclei electrophysiology eye movements gravity head movements neurophysiology otocyst /otolith postdoctoral investigator space perception vestibular nuclei

项目摘要

DESCRIPTION (provided by applicant): Accurate awareness of spatial orientation, which results from complex multidimensional interactions of sensory signals originating from multiple sources and different coordinate systems, is fundamental in maintaining posture as well as ongoing voluntary activities. Signals originating from otolith, semicircular canal, and muscle proprioceptive receptors are examples of such sensory cues required by the CNS to execute reflex control of body posture and movement. The deep cerebellar nuclei are some of the known sites of signal convergence from vestibular and proprioceptive systems. The aims of the proposed project are threefold: (1) To investigate vestibular convergence patterns in the rostral fastigial nucleus (rFN) vestibular only neurons using combinations of 3D rotations and translations (2) To investigate if some of the rFN neurons selectively encode translations and ignore changes in head orientations in relation to gravity. This project aims to quantitatively test this hypothesis using protocols with combinations of translational and tilt motion stimuli. (3) To investigate the coordinate system of encoding translational motion. Specifically, we have hypothesized that there exist rFN neurons that encode translational motion in body coordinates. Using a variety of combinations of vestibular stimulations and single unit electrophysiology, numerous relationships will be examined. The results are important in improving our understanding of the functional role of the deep cerebellar nuclei and of the significance of otolith/canal convergence in the central vestibular system.

描述（由申请人提供）：对空间方位的准确认识，是源于多个来源和不同坐标系的感觉信号的复杂多维相互作用的结果，是保持姿势和持续自愿活动的基础。源自耳石、半规管和肌肉本体感受受体的信号是CNS执行身体姿势和运动的反射控制所需的此类感觉线索的示例。小脑深核是前庭和本体感受系统信号汇聚的已知部位。该项目的目的有三个：（1）研究前庭会聚模式的喙顶核（rFN）前庭神经元使用的组合的三维旋转和平移（2）研究是否有一些rFN神经元选择性编码翻译和忽略头部方向的变化与重力。本项目旨在定量测试这一假设使用协议的组合平移和倾斜运动刺激。(3)研究平移运动编码的坐标系。具体而言，我们假设存在编码体坐标中的平移运动的rFN神经元。使用前庭刺激和单一单位电生理学的各种组合，将检查许多关系。这一结果对于提高我们对小脑深核的功能作用和中央前庭系统耳石/耳道会聚的意义的认识具有重要意义。