Integrated Bioinformatics Center of Cellular Biology

描述(由申请人提供)：本申请旨在开发和开发 筹划细胞生物学领域的卓越生物信息学中心。这个 应用程序规划方面的中心是促进 一组计算科学家和一组生物医学科学家 在计算密集型生物医学研究中。三个发展项目 其中包括虚拟细胞项目、微阵列项目和 质谱学/蛋白质组学项目。各自负责的三个项目 小组集体解决从手机到手机的各种研究问题 从生物学到器官生理学。然而，这些群体分享着非常高的互动 由于它们各自之间的天然关联性而产生的潜力 子学科。计算小组计划引入一系列 计算问题的创新解决方案，其中每一个 发展性群体已经越来越多地面临。计算需要的是 将解决的是生物医学研究的基本问题，因此 其中提出的新方法将不仅解决推动 参与开发项目，也是更广泛类别的生物医学 在其他地方的应用。计算小组的第二个目标是计划和 建立高性能计算基础设施，专门用于 生物信息学研究活动。这项基础设施发展将 最初利用高速网络来互连现有的计算机硬件 和软件资源目前分散在各个实验室。它 将随后成熟为专门用于 生物信息计算。 拟议中的生物信息学中心将采用一项雄心勃勃的计划来彻底改革 生物信息学教育和培训计划，由办公室为 课程开发、学生活动、研讨会和工作坊、博士后 培训、访客编程和计算资源共享。这个 中心？S的职能还包括组织年度务虚会以促进 研究人员、访客管理计划和实习之间的互动 与当地生物医药和制药行业合作的项目。终极的 该中心的目标是满足日益增长的计算密集型需求 在研究中追求创新，同时进行生物医学研究 培训下一代研究人员在这一重要方面 多学科领域。

DESCRIPTION (provided by applicant): This application aims at developing and planning a Bioinformatics Center of Excellence in Cellular Biology. The planning aspect of the application centers on promoting interactions between a group of computational scientists and a group of biomedical scientists engaged in computation intensive biomedical research. The three development projects included are the Virtual Cell project, the Microarray project, and the Mass-Spectrometry/Proteomics project. The respective three responsible project groups collectively address a wide spectrum of research issues from cellular biology to organ physiology. Yet these groups share a very high interaction potential due to the natural relevancy amongst their respective sub-disciplines. The computational group plans to bring in a series of innovative solutions to the computational problems that each of these developmental groups has been increasingly facing. The computational needs that will be addressed are fundamental issues in biomedical research and thus the novel approaches proposed therein will address advancing not only the participating development projects but also a wider class of biomedical applications elsewhere. A second goal of the computational group is to plan and establish a high performance computing infrastructure dedicated to the proposed bioinformatics research activities. This infrastructure development will initially utilize a high-speed network to interlink existing computer hardware and software resources currently scattered around individual laboratories. It will subsequently mature into a central computing facility dedicated to bioinformatic computing. The proposed bioinformatics center will employ an ambitious plan to overhaul bioinformatics education and training programs by officering a focal point for curriculum development, student activities, seminars and workshops, postdoc training, visitors program, and sharing of computational resources. The center?s function also includes organizing annual retreats to promote interactions among researchers, managing visitors programs and internship programs with the local biomedical and pharmaceutical industry. The ultimate goal of the center is to fulfill the growing need of computation intensive biomedical research by pursuing innovation in research and at the same time training the next generation of researchers in this important multi-disciplinary field.