Parenthood after Cancer

描述(申请人提供)：为期3天的科学会议，癌症后为人父母将于2004年3月5日至7日在休斯顿的德克萨斯大学安德森癌症中心举行。其目标是将来自不孕症和肿瘤学领域的基础科学家、临床医生、行为科学家、生物伦理学家和患者倡导者聚集在一起，总结癌症后生育和怀孕以及后代健康方面的研究现状。将讨论以下主题：癌症幸存者在癌症后试图为人父母的心理社会方面；癌症及其治疗对精子自生、卵巢功能和发育中的胚胎的影响的分子模型；癌症治疗期间使用血液保护性腺的当前努力；对接受癌症治疗的男性和女性的生育能力的前瞻性人体研究；修改放射治疗和手术以避免生育；在癌症治疗之前冷冻精子、卵母细胞、胚胎和精原细胞及其在随后的生育治疗中的使用；接受癌症治疗的妇女怀孕的安全性；癌症幸存者所生子女的健康；遗传性癌症综合征对生育决策的影响；患者倡导努力克服知识、资金和获得护理的障碍；患者教育需求；以及国家卫生研究院在这些领域获得研究资金的机会。三场伦理辩论将围绕死后生殖、向冷冻保存卵巢组织收取费用以及对遗传性癌症综合征基因突变进行产前诊断测试展开。与生殖和癌症相关的法律问题也将被讨论。与会者将被邀请为同行评议的海报会议提交摘要。社交和专业互动的时间将在休息和午餐、海报会议和晚餐时提供。会议记录将发表在国家癌症研究所杂志专刊上，并在倡导组织Fer Tile Hope的网站上为患者/幸存者总结。2005年第一季度，一个由大约20名专家组成的工作组将在休斯顿开会，编写一份关于会议所涉领域研究优先事项的报告。2005年第二季度，一个由大约20人组成的工作组将举行会议，起草一份关于生殖与癌症临床指南草案的手稿，提交给相关的同行评议期刊。

DESCRIPTION (provided by applicant): A 3-day scientific meeting, Parenthood after Cancer will take place March 5 to 7, 2004 at the UT M.D. Anderson Cancer Center in Houston. The goal is to bring together basic scientists, clinicians, behavioral scientists, bioethicists, and patient advocates from both the infertility and oncology spheres to summarize the state of art in research on fertility and pregnancy after cancer, and health of offspring. The following topics will be addressed: psychosocial aspects of cancer survivors' experiences in trying to achieve parenthood after cancer; molecular models of the impact of cancer and its treatments on sperm autogenesis, ovarian function, and the developing embryo; current efforts to use hemoprotection of the gonads during cancer treatment; prospective human studies of fertility in men and women undergoing cancer treatment; modification of radiation therapy and surgery to spare fertility; cryopreservation of sperm, oocytes, embryos, and spermatogonia before cancer treatment and their use in subsequent fertility therapies; the safety of pregnancy for women treated for cancer; the health of children born to cancer survivors; the implications of inherited cancer syndromes for childbearing decisions; patient advocacy efforts to overcome barriers of knowledge, finance, and access to care; patient education needs; and opportunities for research funding at the National Institutes of Health in these areas. Three ethical debates will be presented, on posthumous reproduction, charging fees to cryopreserve ovarian tissue, and use of prenatal diagnostic testing for inherited cancer syndrome gene mutations. Legal issues related to reproduction and cancer will also be addressed. Attendees will be invited to submit abstracts for a peer-reviewed poster session. Time for social and professional interaction will be provided at breaks and lunches, the poster session, and a dinner. The proceedings will be published in a special issue of Monographs of the Journal of the National Cancer Institute and summarized for patients/survivors on the website of the advocacy organization, Fer tile Hope. In the first quarter of 2005, a working group of about 20 experts will meet in Houston to prepare a report on research priorities in the areas covered by the conference. In the second quarter of 2005 a working group of around 20 will meet to draft a manuscript on proposed clinical guidelines on reproduction and cancer, for submission to a relevant, peer-reviewed journal.