Reactive Intermediates: The Vanguard

描述（由申请人提供）：本申请为2003年9月8日至10日在纽约市举行的第226届美国化学学会会议寻求半天研讨会的支持，该会议由化学毒理学部主办。研讨会的题目是：“反应性中间体：先锋”，旨在集中讨论与人类健康的化学损害有关的最新的新化学。当然，包括癌症在内的许多疾病的复杂病因都是由生物分子的化学损伤引起的；脂质，蛋白质和DNA在过去三十年中，在确定各种环境和内生来源的损害类型方面取得了相当大的进展。虽然在某些特定的情况下，对潜在的化学事件已经有了相当直接的了解，但越来越明显的是，在最终构成可能影响疾病的损害的化学过程中，存在相当大的复杂性。最初的或主要的损伤实际上可能演变成一系列的附属损伤事件。这些附属事件可能最终负责、加强或以其他方式调节“初始”事件。初始事件和附属事件都是由反应性中间体介导的。了解这些中间体化学的基本方面，它们的结构，反应性和反应产物，对于解剖最终导致关键损害事件的物种至关重要，这些损害事件演变为病态状态。本次研讨会的目的是将了解主要和辅助反应中间体光谱以及引起细胞损伤并引发疾病（特别是癌症）的化学的主要化学家聚集在一起。

DESCRIPTION (provided by applicant): This application seeks support for a half-day symposium to be held at the 226th meeting of the American Chemical Society September 8-10, 2003 in New York City that is sponsored by the Division of Chemical Toxicology. The Symposium is titled: "Reactive Intermediates: The Vanguard" and seeks to focus on the latest novel chemistry relevant to chemical damage in human health. Certainly the complex etiology of many diseases, including cancers, is initiated by chemical damage to biomolecules; lipids, proteins and DNA. Over the last thirty years, considerable progress has been made in characterizing types of damage from a variety of sources both environmental and endogenous. While in some select cases, a reasonably straightforward picture of the underlying chemical events has emerged, it has become increasingly apparent that there is considerable chemical complexity in what ultimately constitutes damage that may affect disease. The initial, or primary, damage may in fact evolve in a series of subsidiary damage events. These subsidiary events may ultimately be responsible for, intensify or otherwise modulate the "initiating" event. Both the initial event and the subsidiary events are mediated by reactive intermediates. Understanding the fundamental aspects of the chemistry of these intermediates, their structure, reactivity and reaction products, is essential in dissecting the species that ultimately give rise to key damage events that devolve to the morbid state. The purpose of this symposium is to bring together leading chemists who are involved in the understanding the spectrum of primary and subsidiary reactive intermediates and the chemistry that gives rise to cellular damage that initiates disease, particularly cancer.