FASEB SUMMER RESEARCH CONFERENCE: TRANSPORT ATPASES

FASEB 夏季研究会议：运输ATP酶

• 批准号: 6597222
• 负责人: GIUSEPPE INESI
• 金额: $ 1.35万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-01 至 2004-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6597222
• 关键词: adenosinetriphosphatase; disease /disorder etiology; enzyme activity; functional /structural genomics; meeting /conference /symposium; transport proteins; travel

DESCRIPTION (provided by applicant): This is an application for partial funding for a FASEB summer research conference titled "Transport ATPases: Genomics, Mechanisms and Relevance to Diseases". The conference will be held in the Vermont Academy, Saxton River, Vermont, on July 12-17, 2003. The Conference was reviewed and approved by the appropriate FASEB Committee, and will be the fourth meeting held every two years on this subject. The major goal of the meeting is to bring together about 150 participants, including the top scientists in this field, but also younger investigators and postdoctoral fellows. The conference schedule include two keynote lectures, nine sessions with 4 talks each, poster viewing and discussion, and a postdoc forum. The subjects of discussion will be: Genomic survey of transport ATPases, crystal structure and mechanism of the Ca 2+ATPase, crystal structure and mechanism of the ABC transporters, transport ATPases in yeast systems, crystal structure and mechanisms of the ATP synthase, comparative ATPase structure and mechanisms, mechanism and modulation of plasma Na+,K+ and Ca 2+ATPases, Ca 2+ATPase in cardiac function and disease, and relevance of transport ATPases to human diseases. In addition to lectures, there will be poster presentations and a post-doc forum to foster communication among more established and younger scientists. It is expected that the conference will be highly significant with regard to both basic and medical sciences. The astounding progress in definition of crystal structures facilitates understanding of mechanisms and open up avenues for modeling and drug development. Furthermore, genomic surveys reveal an increasing number of genetically linked diseases of transport ATPases. Finally, it is clear that pathogenetic features of common disease states, such as heart failure and drug resistance, are related to altered expression and/or function of transport ATPases. The conference is related to the mission of the NHBLI (Ca 2+ and Na+,K+ATPase; ABC transporters), NIAMS (Ca 2+ATPases), NIGMS (all transport ATPases), NIDDK (CFTR, copper ATPase), NCI (MDR/Pglycoprotein and MRP1, and the NEI (ABCR). There is a good representation of established and junior scientists at the meeting, both male and female.

描述（由申请人提供）：这是FASEB夏季研究会议部分资金的申请，题为“运输ATP酶：基因组学，机制和疾病的相关性”。会议将于2003年7月12日至17日在佛蒙特州萨克斯顿河的佛蒙特学院举行。该会议由FASEB适当委员会审查和批准，将是每两年举行一次的关于这一主题的第四次会议。会议的主要目标是汇集约150名与会者，包括该领域的顶尖科学家，但也有年轻的研究人员和博士后研究员。会议日程包括两个主题演讲，9个会议，每个会议4个演讲，海报观看和讨论，以及博士后论坛。讨论的主题将是：转运ATP酶的基因组学研究，Ca 2+ ATP酶的晶体结构和机制，ABC转运蛋白的晶体结构和机制，酵母系统中的转运ATP酶，ATP合酶的晶体结构和机制，比较ATP酶的结构和机制，血浆Na+，K+和Ca 2+ ATP酶的机制和调节，心脏功能和疾病中的Ca 2+ ATP酶，以及转运ATP酶与人类疾病的相关性。除了讲座外，还将举办海报展示和博士后论坛，以促进更成熟和更年轻的科学家之间的交流。预计会议将在基础科学和医学方面具有重要意义。晶体结构定义的惊人进展促进了对机制的理解，并为建模和药物开发开辟了途径。此外，基因组调查揭示了越来越多的遗传相关疾病的运输ATP酶。最后，很明显，常见疾病状态的发病特征，如心力衰竭和耐药性，与转运ATP酶的表达和/或功能改变有关。会议涉及NHBLI（Ca 2+和Na+，K+ ATP酶; ABC转运蛋白）、NIAMS（Ca 2+ ATP酶）、NIGMS（所有转运ATP酶）、NIDDK（CFTR，铜ATP酶）、NCI（MDR/P糖蛋白和MRP 1）和NEI（ABCR）的使命。 与会者中有不少资深科学家和年轻科学家，既有男性也有女性。