Gordon Conference--Ca2+ Signaling

描述(由申请人提供)： 寻求资金用于支付将于7月6日至11日在马萨诸塞州南哈德利的芒特霍利克学院举行的戈登钙信号研究会议的部分支持。这次会议提供了一个独特的多学科论坛，以交流在钙和gt；信号领域的想法和信息，这是从酵母到哺乳动物的所有真核生物共同的一种基本细胞控制形式。会议的一个特别优势是，它能够刺激使用各种有机体和细胞系统的工人之间的国际互动，以及从基本机制到疾病状态的各种兴趣。主要目标是促进新老调查人员之间的成功互动。将优先为初级科学家(学生和博士后实习生)、女科学家、代表性不足的少数群体科学家和国际参与者挑选和提供资金。会议将包括8个讨论会，每个讨论会由一位在最大限度地进行互动交流方面有经验的该领域的杰出成员(老牌和年轻的)领导。还将有两个海报会议。主要会议将强调钙在控制基本细胞功能中的作用。包括质膜上钙离子通量的调节，钙信号事件的空间和时间控制，以及钙信号在感觉系统(嗅觉、味觉、嗅觉、温度)、胞吐、细胞能量学、细胞死亡和心脏和神经元疾病中的作用。主席和发言者包括女科学家(3/8主席和6/24发言者)和一批既有经验又事业有成的年轻调查人员。它们代表了一系列细胞系统和不同的技术，从模型系统和体内钙信号机制的结构和分子生物学分析和操作，到亚细胞隔间的开创性显微成像技术，以观察钙信号的产生和传播。参与者的背景包括生物化学、生理学、细胞生物学、分子生物学、生物物理学和药理学；他们都对了解细胞内钙信号的机制和意义感兴趣。本次会议所包括的议题既非常重要，也直接关系到对重大疾病的了解，包括心血管疾病、神经退行性疾病和感官疾病、衰老、糖尿病、癌症以及环境毒素对人类健康的影响。

DESCRIPTION (provided by applicant): Funds are sought to cover partial support of the Gordon Research Conference on Calcium Signaling to be held at Mount Holyoke College, South Hadley, Massachusetts, July 6-11. The meeting provides a unique multidisciplinary forum for exchange of ideas and information in the field of Ca>signaling, a fundamental form of cellular control common to all eukaryotic organisms, from yeast to mammals. A particular strength of the meeting is its ability to stimulate international interactions between workers using a variety of organisms and cellular systems and with interests that range from fundamental mechanisms to disease states. The primary objective is to facilitate successful interactions between new and established investigators. Highest priority will be given to the selection of, and provision of funds for, junior scientists (student and postdoctoral trainees), women scientists, under-represented minority scientists and international participants. The conference will include 8 discussion sessions, each lead by a prominent member of the field (established and young) with experience in maximizing interactive exchange. There will also be two poster sessions. The main sessions will emphasize the role of Ca 2+ in controlling fundamental cell functions. These include the regulation of Ca 2+ fluxes at the plasma membrane, the spatial and temporal control of Ca 2+ signaling events, and the roles of Ca 2+ signaling in sensory systems (olfaction, taste, smell, temperature), exocytosis, cellular energetics, cell death and cardiac and neuronal diseases. Chairs and speakers include female scientists (3/8 chairs and 6/24 speakers) and a combination of established and successful younger investigators. They represent an array of cellular systems and different techniques ranging from structural and molecular biological analyses and manipulation of the Ca2+ signaling machinery in model systems and in vivo, to pioneering micro-imaging technology in subcellular compartments to observe the generation and propagation of Ca2+ signals. Participants are drawn from backgrounds that include biochemistry, physiology, cell biology, molecular biology, biophysics and pharmacology; all share a primary interest in understanding the mechanisms and significance of Ca 2+ signaling in cells. The topics included at this meeting are both fundamentally important and directly relevant to an understanding of significant diseases, including cardiovascular, neurodegenerative and sensory diseases, ageing, diabetes, cancer, and the effects of environmental toxins on human health.