Conference Proposal: Ion Channel Regulation

描述（由申请人提供）： 这是一个申请的部分支持的首届FASEB夏季会议的离子通道调节将于2003年6月14日至19日在奥姆尼度假村在图森，亚利桑那州。主要议题包括调节通道的表达，分布和活动的信号机制，涉及G蛋白级联，第二信使，蛋白磷酸化，细胞骨架和信号复合体衔接蛋白。还将介绍新的通道功能和信号通路。演讲者将包括著名的科学家，既有成熟的，也有新兴的，他们在过去的18个月里做出了重要的发现，其中一些尚未发表。除了发言，高级妇女将主持大多数会议。大约145名额外的参与者将主要从博士前和博士后学员和年轻的教师中选出，并优先考虑那些提交摘要或在科学领域历史上代表性不足的人。这次会议的一个新特点将是包括讨论会，让学员与发言者进行非正式发言。请拨的资金将用于为初级调查员提供旅费，并部分支付发言者出席会议的费用。这次会议将交替和补充两年一度的戈登会议离子通道，重点是离子通道蛋白的生物物理特性，特别是在电兴奋细胞。从历史上看，离子通道调节研究对于通道会议来说过于生物化学，对于信号会议来说过于生物物理。这次会议旨在汇集来自许多学科的研究人员，生物化学，生物物理学，细胞和分子生物学，生理学和神经科学。离子通道调节研究的许多最新进展，使其成为一个及时和重要的会议主题。已经鉴定了离子通道的新结构家族，其响应于新信号并且在发育、老化和免疫应答中提供非传统细胞功能。离子通道突变也已在人类神经、内分泌、心脏、血管和肾脏及系统疾病中确定。预计调节通道活性的信号通路的中断将对人类健康产生类似的有害后果，因此成功预防和治疗这些疾病将需要更清楚地了解所涉及的分子机制。

DESCRIPTION (provided by applicant): This is an application for partial support of the inaugural FASEB summer conference on Ion Channel Regulation to be held June 14-19, 2003 at the Omni Resort in Tucson, AZ. Major topics to be covered include regulation of channel expression, distribution and activity by signaling mechanisms involving G protein cascades, second messengers, protein phosphorylation, cytoskeleton and signaling complex adapter proteins. Novel channel functions and signaling pathways will also be presented. Speakers will include prominent scientists, both established and emerging, who have made important discoveries in the past 18 months, some still unpublished. In addition to speaking, senior women will chair most sessions. Approximately 145 additional participants will be selected predominantly from pre-and postdoctoral trainees and young faculty, and priority will be given to those who present abstracts or have been historically underrepresented in science. A novel feature of this meeting will be the inclusion of discussion sessions for trainees to speak informally with speakers. Requested funds will be used to provide travel awards for junior investigators and to partially defray the costs of speakers' attendance. This meeting will alternate with and complement the biennial Gordon Conference on ion channels, which focuses on the biophysical properties of ion channel proteins, particularly in electrically excitable cells. Historically ion channel regulation research has been too biochemical for channel meetings, and too biophysical for signaling meetings. This conference is designed to bring together investigators from many disciplines, biochemistry, biophysics, cell and molecular biology, physiology and neuroscience. Many recent advances have occurred in ion channel regulation research, making this a timely and important conference topic in its own right. New structural families of ion channels have been identified that respond to novel signals and serve non-traditional cellular functions in development, in aging and in immune responses. Ion channel mutations have also been identified in human diseases of the nervous, endocrine, cardiac, vascular and renal and systems. It is expected that disruption of the signaling pathways that regulate channel activity will have similar deleterious consequences for human health, so successful prevention and treatment of these diseases will require a clearer understanding of the molecular mechanisms involved.