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Studies of the Flora and Predator Bacteria of Jordan

约旦植物区系和捕食者细菌的研究

基本信息

批准号：
6805230
负责人：
NICHOLAS H. OBERLIES
金额：
$ 23.23万
依托单位：
RESEARCH TRIANGLE INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-09-30 至 2006-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6805230
关键词：
Middle East antibiotics antineoplastics bacteria biological products centrally acting drug drug discovery /isolation drug screening /evaluation ecology folk medicine geographic difference international cooperation medicinal plants plant ecology plant extracts training

项目摘要

DESCRIPTION (provided by applicant): This R21 planning application proposes the development of an International Cooperative Biodiversity Group (ICBG) to investigate the biodiversity of the Hashemite Kingdom of Jordan (Jordan) for bioactive lead compounds useful for the treatment of human diseases and/or as viable agrochemicals (fungicides, larvacides, pesticides, etc.). The proposed studies build upon the historical successes, strong formal collaborations, and long-standing personal relationships between researchers at the Research Triangle Institute of North Carolina (RTI), the Virginia Polytechnic Institute and State University (VT), and the Jordan University of Science and Technology of Irbid, Jordan (JUST). Biodiversity proposed for investigation encompasses Jordanian plants and traditional botanicals, and the innovative area of Predator bacteria. Compound discovery focuses on three primary pharmacological areas: antimicrobial activity, anticancer activity, and central nervous system (CNS) activity. The six specific program areas are: 1) Flora for Lead Discovery from under-investigated Jordanian plants from diverse and unique environments (Botany and Biodiversity), 2) Flora for Herbal Drug Analysis based on safety and efficacy of medicinal plants used traditionally by the People of Jordan (Botany and Ethnobotany), 3) Predator Bacteria from the diverse topographical regions of Jordan (Microbiology and Biodiversity), 4) Bioassays for Lead Discovery in anticancer, antimicrobial, and CNS pharmacology and prescreening for general toxicity in the brine shrimp test (Pharmacology, Microbiology, and Toxicology), 5) Natural Products Chemistry to isolate, purify, and characterize bioactive lead compounds based on bioactivitybased fractionation and development of analytical reference compounds and standardization protocols for the analysis of commonly used Jordanian herbal medicinals (Pharmacognosy), and 6) Education, Training, and Economic Development for technology transfer in the form of course instruction and workshops in Jordan, training of Jordanian researchers and students in advanced chemical and pharmacological techniques at RTI and VT, and by stimulating and encouraging economic development opportunities resulting from the collective scientific output of the research team. Intellectual property rights and consideration of the People of Jordan have been agreed to in principle and plans for formalization of these agreements are outlined herein.

描述(由申请人提供)：这份R21规划申请建议建立一个国际合作生物多样性小组(ICBG)，以调查约旦哈希姆王国(约旦)的生物多样性，寻找可用于治疗人类疾病和/或作为可行的农用化学品(杀菌剂、杀虫剂、杀虫剂等)的生物活性铅化合物。拟议的研究建立在北卡罗来纳州三角研究所(RTI)、弗吉尼亚理工学院和州立大学(VT)以及约旦伊尔比德科技大学(JUST)的研究人员之间的历史成功、强有力的正式合作和长期的个人关系的基础上。建议调查的生物多样性包括约旦植物和传统植物，以及捕食者细菌的创新领域。化合物的发现主要集中在三个主要的药理领域：抗微生物活性、抗癌活性和中枢神经系统(CNS)活性。这六个具体计划领域是：1)从不同和独特环境中调查不足的约旦植物中发现铅的植物群(植物学和生物多样性)，2)基于约旦人传统使用的药用植物的安全性和有效性的草药分析植物群(植物学和民族植物学)，3)约旦不同地形地区的捕食者细菌(微生物学和生物多样性)，4)抗癌、抗菌和中枢神经系统药理学中铅发现的生物测试方法和卤虾试验中一般毒性的预筛选(药理学、微生物学和毒理学)，5)天然产品化学分离、纯化、6)以生物活性为基础的分离和开发分析参考化合物和约旦常用草药分析的标准化协议(生药学)为基础的生物活性先导化合物；6)教育、培训和经济发展，以约旦课程教学和讲习班的形式转让技术，在RTI和VT对约旦研究人员和学生进行先进化学和药理技术培训，并刺激和鼓励研究小组集体科学成果带来的经济发展机会。原则上同意知识产权和约旦人民的考虑，并在此概述了这些协定正规化的计划。