Studies of the Flora and Predator Bacteria of Jordan

描述（由申请人提供）：本R21规划申请建议建立国际生物多样性合作小组（ICBG），以调查约旦哈希姆王国（约旦）的生物多样性，以寻找可用于治疗人类疾病和/或作为可行农用化学品（杀真菌剂、杀幼虫剂、杀虫剂等）的生物活性先导化合物。拟议的研究建立在历史上的成功，强大的正式合作，并在研究三角研究所的北卡罗来纳州（RTI），弗吉尼亚理工学院和州立大学（VT），和约旦科技大学的伊尔比德，约旦（JUST）的研究人员之间的长期个人关系。拟议调查的生物多样性包括约旦植物和传统植物，以及捕食者细菌的创新领域。化合物发现集中在三个主要药理学领域：抗微生物活性、抗癌活性和中枢神经系统（CNS）活性。这六个具体方案领域是：1）从不同和独特环境中未充分调查的约旦植物中发现铅的植物群（植物学和生物多样性），2）用于草药分析的植物群，基于约旦人民传统使用的药用植物的安全性和功效（植物学和民族植物学），3）来自约旦不同地形区域的捕食者细菌（微生物学和生物多样性），4）抗癌、抗微生物和CNS药理学中铅发现的生物测定以及卤虫试验中一般毒性的预筛选（药理学、微生物学和毒理学），5）天然产物化学以分离、纯化，并基于基于生物活性的分级和分析参考化合物的开发以及标准化来表征生物活性先导化合物约旦常用草药分析方案6）教育、培训和经济发展促进技术转让，在约旦举办课程教学和讲习班，在RTI和VT培训约旦研究人员和学生掌握先进的化学和药理学技术，以及通过刺激和鼓励研究团队集体科学产出所带来的经济发展机会。已原则上同意知识产权和约旦人民的考虑，本文件概述了使这些协议正式化的计划。

DESCRIPTION (provided by applicant): This R21 planning application proposes the development of an International Cooperative Biodiversity Group (ICBG) to investigate the biodiversity of the Hashemite Kingdom of Jordan (Jordan) for bioactive lead compounds useful for the treatment of human diseases and/or as viable agrochemicals (fungicides, larvacides, pesticides, etc.). The proposed studies build upon the historical successes, strong formal collaborations, and long-standing personal relationships between researchers at the Research Triangle Institute of North Carolina (RTI), the Virginia Polytechnic Institute and State University (VT), and the Jordan University of Science and Technology of Irbid, Jordan (JUST). Biodiversity proposed for investigation encompasses Jordanian plants and traditional botanicals, and the innovative area of Predator bacteria. Compound discovery focuses on three primary pharmacological areas: antimicrobial activity, anticancer activity, and central nervous system (CNS) activity. The six specific program areas are: 1) Flora for Lead Discovery from under-investigated Jordanian plants from diverse and unique environments (Botany and Biodiversity), 2) Flora for Herbal Drug Analysis based on safety and efficacy of medicinal plants used traditionally by the People of Jordan (Botany and Ethnobotany), 3) Predator Bacteria from the diverse topographical regions of Jordan (Microbiology and Biodiversity), 4) Bioassays for Lead Discovery in anticancer, antimicrobial, and CNS pharmacology and prescreening for general toxicity in the brine shrimp test (Pharmacology, Microbiology, and Toxicology), 5) Natural Products Chemistry to isolate, purify, and characterize bioactive lead compounds based on bioactivitybased fractionation and development of analytical reference compounds and standardization protocols for the analysis of commonly used Jordanian herbal medicinals (Pharmacognosy), and 6) Education, Training, and Economic Development for technology transfer in the form of course instruction and workshops in Jordan, training of Jordanian researchers and students in advanced chemical and pharmacological techniques at RTI and VT, and by stimulating and encouraging economic development opportunities resulting from the collective scientific output of the research team. Intellectual property rights and consideration of the People of Jordan have been agreed to in principle and plans for formalization of these agreements are outlined herein.