EXTRAMURAL RESEARCH FACILITIES IMPROVEMENT PROVEMENT

描述(由申请人提供)： 需要配套资金翻修霍华德大厅六楼22,500 GSFs的建筑面积，以扩大和改善巴尔的摩马里兰大学医学院的集中实验动物资源。这一新的最先进的动物资源将具有目前缺乏的组成部分。这一部分是一个功能齐全的动物生物安全3级遏制设施，致力于支持医学院具有非凡国家重要性的国际公认的计划，包括新出现的病原体、生物恐怖主义和生物防御方面的计划。这包括由NIH支持的传染病司、流行病学部、疫苗开发中心、微生物学和免疫学部、医学部地理医学部以及新成立的新兴病原体研究中心进行的研究。 该项目的目标是增加、加强和现代化现有的实验动物资源，并提供适当的设施，以满足教师的常规和专门研究需求。 具体目标是：满足对更多动物和支持空间的迫切需求，并跟上不断扩大的动物普查的步伐，同时增加涉及使用实验室动物的PHS和非PHS资金，以提供高度专业化的生物危害遏制资源和支持空间，以满足涉及动物生物危害因子的正在进行的和正在进行的研究项目，并提供中央资源，用于安置和鉴定转基因和免疫受损的啮齿动物，以及为非人类灵长类动物检疫和其他物种提供常规空间。

DESCRIPTION (provided by applicant): Matching funds are requested to renovate 22,500 GSFof floor space on the Howard Hall sixth floor to expand and improve the centralized laboratory animal resources at the School of Medicine, University of Maryland, Baltimore. This new state-of-the-art animal resource will feature a component that is currently lacking. This component is a fully functional Animal Biosafety Level 3 containment facility dedicated to supporting the School of Medicine's internationally recognized programs of extraordinary national importance including programs in both emerging pathogens, bioterrorism and biodefense. This includes NIH-supported studies by the Division of Infectious Diseases, the Department of Epidemiology, the Center for Vaccine Development, the Department of Microbiology and Immunology, and the Department of Medicine's Division of Geographic Medicine, as well as the new Emerging Pathogens Research Center. The objectives of this project are to augment, enhance, and modernize the existing laboratory animal resources and to provide appropriate facilities to meet the conventional and specialized research needs of the faculty. Specific aims are: to address the pressing need of additional animal and support space, and to keep pace with an expanding animal census along with increased PHS- and non-PHS funding involving the use of laboratory animals to provide the highly specialized biohazard containment resources and support space required to meet active and pending research projects involving biohazard agents in animals and to provide centralized resources for housing and characterizing genetically altered and immuno-compromised rodents, as well as conventional space for non-human primate quarantine and other species.