EXTRAMURAL RESEARCH FACILITIES IMPROVEMENT PROVEMENT

描述（由申请人提供）： 请求配套资金翻新霍华德大厅六楼 22,500 GSFof 的建筑面积，以扩大和改善巴尔的摩马里兰大学医学院的集中实验动物资源。 这种新的最先进的动物资源将具有目前缺乏的成分。 该组件是一个功能齐全的动物生物安全 3 级遏制设施，致力于支持医学院国际公认的具有非凡国家重要性的项目，包括新兴病原体、生物恐怖主义和生物防御方面的项目。 这包括 NIH 支持的传染病司、流行病学司、疫苗开发中心、微生物学和免疫学司、医学系地理医学司以及新的新兴病原体研究中心的研究。 该项目的目标是扩大、加强和现代化现有的实验动物资源，并提供适当的设施来满足教师的常规和专业研究需求。 具体目标是：解决对额外动物和支持空间的迫切需求，并跟上不断扩大的动物普查，以及涉及使用实验动物的小灵通和非小灵通资金的增加，提供高度专业化的生物危害遏制资源和支持空间，以满足涉及动物生物危害因子的活跃和悬而未决的研究项目，并提供集中资源用于住房和表征转基因和免疫受损的啮齿动物，以及非人类灵长类检疫和其他物种的常规空间。

DESCRIPTION (provided by applicant): Matching funds are requested to renovate 22,500 GSFof floor space on the Howard Hall sixth floor to expand and improve the centralized laboratory animal resources at the School of Medicine, University of Maryland, Baltimore. This new state-of-the-art animal resource will feature a component that is currently lacking. This component is a fully functional Animal Biosafety Level 3 containment facility dedicated to supporting the School of Medicine's internationally recognized programs of extraordinary national importance including programs in both emerging pathogens, bioterrorism and biodefense. This includes NIH-supported studies by the Division of Infectious Diseases, the Department of Epidemiology, the Center for Vaccine Development, the Department of Microbiology and Immunology, and the Department of Medicine's Division of Geographic Medicine, as well as the new Emerging Pathogens Research Center. The objectives of this project are to augment, enhance, and modernize the existing laboratory animal resources and to provide appropriate facilities to meet the conventional and specialized research needs of the faculty. Specific aims are: to address the pressing need of additional animal and support space, and to keep pace with an expanding animal census along with increased PHS- and non-PHS funding involving the use of laboratory animals to provide the highly specialized biohazard containment resources and support space required to meet active and pending research projects involving biohazard agents in animals and to provide centralized resources for housing and characterizing genetically altered and immuno-compromised rodents, as well as conventional space for non-human primate quarantine and other species.