ANIMAL FACILITIES RENOVATION TO ENHANCE RESEARCH

改造动物设施以加强研究

• 批准号: 6560082
• 负责人: RICHARD Brian HUNEKE
• 金额: $ 94.07万
• 依托单位: DREXEL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-01 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6560082
• 关键词: Rodentias; animal colony; behavior test; biomedical facility; building /facility design /renovation; immunology; isolation /quarantine; microbiology; neurobiology; transplantation; university

DESCRIPTION (provided by applicant): The long-term objective is to enhance research productivity at MCP Hahnemann University by renovating the QL animal facility to provide procedural, surgical, quarantine and storage space for the current and known future research needs of the faculty. The QL campus is the site of intensive, National Institutes of Health (NIH)-supported research and training in neurobiology, microbiology and immunology. These programs involve transplantation, immunological interventions, neurophysiological measurements and behavioral assessments in animals. The animal facility has neither general procedural nor dedicated rodent surgical space. Thus, animals must be transported through public corridors into investigators' laboratories and then returned to the facility. This can stress animals, expose them to environmental pathogens, and thereby threaten control of the experimental variables. Additionally, neither of the University's two campuses contain quarantine space for incoming animals (particularly rodents). This has delayed wider incorporation of genetically modified animals into the research. Finally, space for storing racks and cages is urgently needed. The specific aims are: 1) to provide dedicated procedural space for biomedical and behavioral procedures in animals by renovating the existing animal facility, 2) to relocate surgical areas for rodents from investigators' laboratories into new space within the facility, 3) to construct quarantine space at the QL facility to serve research at both campuses of the University, and 4) to remodel space for housing animals and storing racks and cages to enhance operating function of the QL facility. Together, these modifications will dramatically improve our ability to perform health-related studies using animals and will free space within laboratories for additional research activities.

描述（由申请人提供）： 长期目标是通过翻新QL动物设施来提高MCP哈内曼大学的研究生产力，为教师当前和已知的未来研究需求提供程序，手术，检疫和储存空间。 QL校园是密集的，美国国立卫生研究院（NIH）支持的神经生物学，微生物学和免疫学研究和培训的网站。 这些项目涉及移植、免疫干预、神经生理学测量和动物行为评估。 动物机构既没有一般手术空间，也没有专门的啮齿动物手术空间。 因此，动物必须通过公共走廊运送到研究者的实验室，然后返回设施。 这会给动物造成压力，使它们暴露于环境病原体，从而威胁到对实验变量的控制。 此外，该大学的两个校区都没有为传入的动物（特别是啮齿动物）提供检疫空间。 这推迟了转基因动物更广泛地纳入研究。 最后，迫切需要存放货架和笼子的空间。 具体目标是：1）通过翻新现有的动物设施，为动物的生物医学和行为程序提供专用的程序空间，2）将啮齿动物的手术区域从研究者的实验室搬迁到设施内的新空间，3）在QL设施建造检疫空间，以服务于大学两个校区的研究，及4）改建饲养动物及储存架和笼舍的空间，以加强QL设施的运作功能。 总之，这些修改将大大提高我们使用动物进行健康相关研究的能力，并将在实验室内腾出空间进行额外的研究活动。