Maternal antidepressant use and fetal neurobehavior

描述(由申请人提供)：拟议研究的总体目标 职业发展计划是为了让调查员艾米·索尔兹伯里博士 作为一名胎儿行为领域的独立调查员 发展与产妇心理健康。调查员在这些领域的重点 代表着一种强烈的愿望，希望了解 儿童精神疾病的发展。作为实现以下目标的第一步 长期目标，索尔兹伯里博士将研究胎儿和新生儿的神经行为 通过结构化访谈诊断出患有严重抑郁障碍(MDD)的女性 使用和不使用抗抑郁药(S SRI)暴露。这项研究将被执行 对高危胎儿和新生儿进行强化的方法学培训(Dr。 Barry Lester)，胎儿监测技术(Janet DiPietro博士)，结构化 面谈技巧(SCID、SADS)和持续的教学培训和临床 情绪障碍和药物治疗领域的顶级专家的监督 妇女的管理(凯瑟琳·威斯纳博士和特里·皮里斯坦博士)，以及 母胎医学(斯蒂芬·卡尔博士)莱斯特博士将担任 该计划的主要导师和整个奖项中的资源提供者 句号。其他技能将通过研究课程获得。 布朗大学的设计和回归分析以及高级 产科超声培训。拟议的职业发展方案将 建立在索尔兹伯里博士成熟的研究和临床技能的基础上 新生儿的行为。调查员得到了布朗医疗队的全力支持 学校、妇幼医院和她的赞助商，以实现这些目标 在这一职业发展计划中概述。广泛而长期的目标是 研究计划是确定SSRI是否有不同的影响 暴露和MDD对胎儿和新生儿神经行为发育的影响。数据 将提供有关胎儿中枢神经系统如何反应的信息 生物环境以及对迫切需要的 关于妊娠期情绪障碍治疗指南的信息。这个 拟议研究计划的具体目标是：1.确定 母亲S SRI治疗MDD(优心期)与非SSRI暴露的活动性MDD比较 胎儿神经行为与对照，2.确定母体S的影响 SRI治疗MDD与非SSRI暴露的活动性MDD对新生儿神经行为和 控制。这项研究的第二个目的是检查 胎儿至新生儿神经行为测量的个体差异 句号。

DESCRIPTION (provided by applicant): The overall goal of the proposed research career development program is to prepare the investigator, Dr. Amy Salisbury, for a career as an independent investigator in the areas of fetal behavioral development and maternal mental health. The investigator's focus in these areas represents a strong aspiration to understand the mechanisms and mediators in the development of childhood mental illness. As a first step in achieving the long-term goals, Dr. Salisbury will study fetal and newborn neurobehavior in women with Major Depressive Disorder (MDD), diagnosed by structured interview, with and without antidepressant (S SRI) exposure. This study will be executed with intensive training in methodologies with at-risk fetuses and newborns (Dr. Barry Lester), fetal monitoring techniques (Dr. Janet DiPietro), structured interview techniques (SCID, SADS) and ongoing didactic training and clinical supervision with top experts in the field of mood disorders and medication management in women (Dr. Katherine Wisner and Dr. Teri Pearistein), and maternal-fetal medicine (Dr. Stephen Carr). Dr. Lester will serve as the primary mentor of this program and resource provider throughout the award period. Additional skills will be attained through coursework on research design and regression analyses at Brown University as well as advanced obstetric ultrasound training. The proposed program of career development will build on Dr. Salisbury's established research and clinical skills in fetal and newborn behavior. The investigator has the full support of the Brown Medical School, Women & Infants' Hospital, and her sponsors to achieve the goals outlined in this career development program. The broad, long-term objective of the research plan is to determine if there are differential effects of SSRI exposure and MDD on fetal and newborn neurobehavioral development. The data will provide information about how the fetal CNS responds to the two maternal biological environments as well as contribute to the urgently needed information for treatment guidelines of mood disorders during pregnancy. The specific aims of the proposed research plan are 1. To determine the effect of maternal S SRI-treated MDD (euthymic) versus nonSSRI exposed active MDD on fetal neurobehavior and controls, 2. To determine the effect of maternal S SRI-treated MDD versus non-SSRI exposed active MDD on newborn neurobehavior and controls. A secondary aim of this study is to examine the stability of the individual differences of neurobehavioral measures from the fetal to newborn period.