Neural Adaptation and Temporal Integration

神经适应和时间整合

• 批准号: 6737645
• 负责人: Marcia Jean Hay-McCutcheon
• 金额: $ 2.96万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-15 至 2004-08-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6737645
• 关键词: acoustic nerve; auditory threshold; brain electrical activity; clinical research; cochlear implants; electrodes; human subject; loudness; neural information processing; neurophysiology; predoctoral investigator

Currently, cochlear implant devices are designed to stimulate auditory nerve fibers at rapid rates of presentation (...i e ,>1000 pulses/second). With. increased stimulation rates, the auditory., nerve shows the effects of adaptation. The amount of adaptation has been shown to vary across ind_wduals and across electrodes within an individual. This adapted neural response will be related to the input to the central integrator, or central auditory system, and it is possible that the time course of adaptation could affect the degree of temporal integration. The objective of this study, therefore, is to identify the relationship between peripheral neural adaptation and behavioral temporal integration in cochlear implant recipients. It is anticipated that information from this study will have direct application for the setting of individual cochlear implant devices. Neural adaptation will be measured by tracking amplitude changes of the electrically evoked compound action potential (ECAP) to varying lengths of rapid rate biphasic pulse trains. Temporal integration will be assessed through the use of a loudness balancing procedure and through the use of two threshold measures. Both electrophysical and psychophysical measures will be performed along the electrode array and across individual cochlear implant recipients. Correlation and linear regression analyses will be used to determine the relationship between neural adaptation and temporal integration.

目前，人工耳蜗植入装置被设计成以快速的呈现率刺激听觉神经纤维（…即>1000脉冲/秒）。以.增加刺激率，听觉，神经表现出适应的效果。适应的量已被证明在个体内跨indweldness和跨电极变化。这种适应的神经反应将与中央整合器或中央听觉系统的输入有关，并且适应的时间过程可能会影响时间整合的程度。因此，本研究的目的是确定人工耳蜗植入者周围神经适应和行为时间整合之间的关系。预计本研究的信息将直接应用于个体人工耳蜗植入器械的设置。将通过跟踪电诱发复合动作电位（ECAP）的振幅变化来测量神经适应，以改变快速双相脉冲串的长度。时间 将通过使用响度平衡程序和通过使用两个阈值测量来评估整合。电物理和心理物理测量都将沿着电极阵列和跨个体耳蜗植入受体进行沿着。相关性和线性回归分析将被用来确定神经适应和时间整合之间的关系。