Smoking Cessation for Women at Risk of Cervical Cancer

有宫颈癌风险的女性戒烟

• 批准号: 6796871
• 负责人: JESSICA A WHITELEY
• 金额: $ 7.35万
• 依托单位: MIRIAM HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-01 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6796871
• 关键词: behavioral /social science research tag; cancer prevention; cancer risk; cervix neoplasms; clinical research; clinical trials; cognitive behavior therapy; counseling; female; group therapy; human subject; human therapy evaluation; nicotine replacement; patient oriented research; smoking; smoking cessation; telemedicine; tobacco abuse; women' s health

DESCRIPTION (provided by applicant): Cigarette smoking has been found to be associated with a two-fold increased risk of developing cervical neoplasia or squamous cell cancer. The constituents of smoke, in concert with human papillomavirus (HPV), may promote the development or progression of cervical neoplasia. Thus, women who are positive for HPV and who smoke are at increased risk for developing cervical cancer. Counseling regarding smoking cessation may be of particular benefit for women undergoing screening at a colposcopy clinic for the evaluation of an abnormal Papanicolaou (Pap) smear. This is considered to be a "teachable moment" for smoking cessation, in that the perceived risk of progression to cervical cancer is heightened. Smoking cessation can reduce this risk as well as other health risks. Additionally, women at the colposcopy clinic represent underserved female smokers in that they are young, of low socioeconomic status, and are more likely to be ethnic or racial minorities. In Phase I, three focus groups of 8 -10 women each will be conducted to adapt an efficacious group-based cognitive-behavioral smoking cessation intervention that is tailored to the needs of women. The adaptations will include modifying the intervention from a group to phone-based delivery format and addressing the unique smoking cessation barriers of the women at our study site colposcopy clinic. In Phase II, the refined materials will be used in a randomized pilot study. Thirty women will be randomized either to an AHRQ + Enhanced Smoking Cessation group (n = 15) or to an AHRQ + Contact Control group (n = 15). Both groups will receive the AHRQ guidelines for smoking cessation (self help materials, brief counseling, recommendation for nicotine replacement therapy) plus phone delivery of either the adapted smoking cessation intervention (AHRQ + Enhanced Cessation) or a health education intervention (AHRQ + Contact Control). Our primary hypothesis is that the women randomized to the AHRQ + Enhanced Cessation group will have higher quit rates then women in the AHRQ + Contact Control group. Thus, we seek to: 1) conduct the formative work to adapt the cessation materials from a group to phone-based format and to address the needs of this population, 2) pilot the recruitment strategy, and 3) conduct a small randomized pilot trial to determine the preliminary efficacy of the materials for smoking cessation. This study, therefore, will serve as a pilot for a larger clinical trial.

描述（由申请人提供）： 研究发现，吸烟与患宫颈肿瘤或鳞状细胞癌的风险增加两倍有关。吸烟的成分，与人乳头瘤病毒（HPV），可能会促进宫颈癌的发展或进展。因此，HPV阳性和吸烟的妇女患宫颈癌的风险增加。关于戒烟的咨询可能对在阴道镜诊所接受筛查以评估异常巴氏涂片的妇女特别有益。这被认为是戒烟的“可教时刻”，因为人们认为宫颈癌进展的风险会增加。戒烟可以降低这种风险以及其他健康风险。此外，阴道镜检查诊所的妇女代表了服务不足的女性吸烟者，因为她们年轻，社会经济地位低，更有可能是少数民族或种族。在第一阶段，将进行三个焦点小组，每组8 - 10名妇女，以适应有效的基于小组的认知行为戒烟干预，这是针对妇女的需要。调整将包括将干预措施从小组修改为基于电话的交付形式，并解决我们研究中心阴道镜诊所女性独特的戒烟障碍。在第二阶段，精制材料将用于随机试点研究。将30名女性随机分配至AHRQ +加强戒烟组（n = 15）或AHRQ +接触对照组（n = 15）。两组都将接受AHRQ戒烟指南（自助材料、简短咨询、尼古丁替代疗法建议），并通过电话提供适应性戒烟干预（AHRQ +增强戒烟）或健康教育干预（AHRQ +接触控制）。我们的主要假设是，随机分配到AHRQ +增强戒烟组的女性戒烟率高于AHRQ +接触控制组的女性。因此，我们力求：1）进行初步工作，将戒烟材料从一组调整为基于电话的格式，并满足这一人群的需求，2）试行招募策略，3）进行小型随机试点试验，以确定戒烟材料的初步疗效。因此，这项研究将作为更大规模临床试验的试点。