Molecular subtypes of cancer-associated fibroblast (CAF) and personalised targeting in Pancreatic Ductal Adenocarcinoma

胰腺导管腺癌（Pancreatic ductal adencarcinoma， PDAC）是致死性肿瘤之一；以广泛的结缔组织增生为特征的癌症相关成纤维细胞（CAF）是这种基质的关键居民，并协调肿瘤的进展。据我们所知，我们首次鉴定出四种具有不同功能特征的CAF分子亚型。我们假设caf的这种异质性可能反映了PDAC患者对治疗的不同反应。在这里，我们将从不同的小鼠模型中开发亚型特异性CAF：癌症共培养物，并确定潜在的治疗靶点或疗法。我们预计我们的结果可能为基于CAF亚型的PDAC个性化靶向治疗铺平道路。

Pancreatic ductal Adenocarcinoma (PDAC) is one of the lethal cancer types; characterized by an extensive desmoplastic stroma. Cancer-associated fibroblasts (CAF) are key residents of this stroma and orchestrate tumor progression. We identified for the first time (to our knowledge) four molecular CAF subtypes with distinct functional characteristics. We hypothesise that this heterogeneity in CAFs may reflect differential responses to therapy in PDAC. Here, we will develop subtype-specific CAF:cancer co-cultures from different mouse models and identify potential therapeutic targets or therapies. We anticipate that our results might pave a way for personalised targeting of PDAC based on CAF subtypes.