Effects of SCI on Female Autonomic Responses

SCI 对女性自主反应的影响

• 批准号: 6685796
• 负责人: MARCA L SIPSKI
• 金额: $ 52.43万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-01-01 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6685796
• 关键词: adrenergic agents; arousal; autonomic nervous system; biological models; clinical research; female; human subject; human therapy evaluation; laboratory rat; magnetic resonance imaging; multiple sclerosis; nervous system disorder therapy; neuropharmacology; neurophysiology; neuropsychology; patient oriented research; reproductive system; self stimulation; sex behavior; sex behavior disorder; somatic reflex; spinal cord injury; spinal reflex; stimulus /response; vagina; vasoconstriction

DESCRIPTION (provided by applicant): The long term aims of this project are to: 1) understand the effect of varying degrees and levels of SCI and dysfunction (SCI/D) on female sexual response: 2) identify the specific neuronal pathways involved in female sexual responses; and 3) develop and evaluate new assessment and treatment methods for neurogenic sexual dysfunction in women. In this project, we plan to build upon our findings in women with SCI to study sexual response in human females with SCD secondary to multiple sclerosis (MS). We will study sexual arousal and orgasm in women with MS to see if similar effects as in women with SCIs can be documented based upon the extent and location of their SCD. We will provide anatomical confirmation of our human findings by studying the urethrogenital (UG) reflex model, a spinal sexual reflex and vaginal changes in the rat. We will study rats that are intact, with bilateral hypogastric, pelvic and pudendal nerve cuts in order to determine the contribution of the sympathetic, parasympathetic and somatic nervous system in regulating genital arousal and orgasm. Peripheral and brain stimulation will be performed in order to mimic peripheral and psychogenic sexual stimulation. We will also test the effects of pharmacologic manipulation of the sympathetic nervous system (SNS) on sexual arousal in women with SCD and will test two treatment protocols aimed at retraining reflex orgasm in women with neurogenic FSD. Our central hypotheses are: 1) In females, the SNS regulates psychogenic genital vasocongestion 2) In females the orgasmic reflex requires the presence of an intact sacral spinal cord 3) In females a pattern generator is responsible for the orgasmic reflex 4) In females with SCIID and preserved sympathetic innervation to the genitals, pharmacologic sympathetic manipulation will alter genital responsiveness and 5) In females with neurogenic sexual dysfunction of spinal etiology use of a clitoral vacuum pump and vibratory stimulation will improve orgasmic ability. This grant represents a new collaborative effort between a long-standing research team led by physiatrist and a basic scientist, all with extensive experience studying female sexual response after neurologic lesions. These studies will provide information about the expected impact of SCD on female sexual response along with anatomical confirmation of the findings in the rat and test three treatment protocols for neurogenic sexual dysfunction.

描述（由申请人提供）：该项目的长期目标是：1）了解不同程度和水平的 SCI 和功能障碍（SCI/D）对女性性反应的影响：2）确定参与女性性反应的特定神经元通路； 3）开发和评估女性神经源性性功能障碍的新评估和治疗方法。 在这个项目中，我们计划基于对患有 SCI 的女性的研究结果，研究继发于多发性硬化症 (MS) 的 SCD 的人类女性的性反应。 我们将研究患有 MS 的女性的性唤起和性高潮，看看是否可以根据 SCD 的程度和位置来记录与 SCI 女性类似的影响。我们将通过研究大鼠的尿道生殖（UG）反射模型、脊髓性反射和阴道变化，从解剖学上证实我们的人类发现。 我们将研究双侧腹下神经、骨盆神经和阴部神经切断的完好大鼠，以确定交感神经、副交感神经和躯体神经系统在调节生殖器唤醒和性高潮中的作用。将进行外周和大脑刺激，以模仿外周和心因性刺激。我们还将测试交感神经系统 (SNS) 的药物操作对 SCD 女性性唤起的影响，并将测试两种旨在重新训练神经源性 FSD 女性反射性高潮的治疗方案。我们的中心假设是： 1) 在女性中，SNS 调节心因性生殖器血管充血 2) 在女性中，性高潮反射需要存在完整的骶脊髓 3) 在女性中，模式发生器负责性高潮反射 4) 在患有 SCIID 且生殖器保留交感神经支配的女性中，药物交感神经操作将改变生殖器 5) 对于患有脊柱病因神经性性功能障碍的女性，使用阴蒂真空泵和振动刺激将提高性高潮能力。 这笔资助代表了由理疗师和基础科学家领导的长期研究团队之间的一项新的合作努力，他们都在研究神经损伤后女性性反应方面拥有丰富的经验。 这些研究将提供有关 SCD 对女性性反应的预期影响的信息，以及对大鼠研究结果的解剖学证实，并测试三种神经源性性功能障碍的治疗方案。