Differential TNF receptor signalling in the regulation and resolution of acute inflammation

差异 TNF 受体信号传导在急性炎症调节和解决中的作用

• 批准号: 2290128
• 金额: --
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2290128
• 关键词: Differential; TNF; receptor; signalling; regulation

The research involves the exploration of TNFR1 and TNFR2 signalling in acute inflammation, looking particularly at the roles of these receptors in the lung. Investigation on mechanisms of organ injury via TNFR1 signalling and whether inhibition of TNFR1 using a domain antibody can prevent the development of lung injury. Another aspect of the project includes investigation of downstream TNFR2 signalling and how it may provide protection to during inflammation.

该研究涉及探索TNFR1和TNFR2在急性炎症中的信号传导，特别关注这些受体在肺中的作用。研究通过TNFR1信号传导的器官损伤机制以及使用域抗体抑制TNFR1是否可以预防肺损伤的发生。该项目的另一个方面包括研究下游TNFR2信号传导以及它如何在炎症期间提供保护。