Differential TNF receptor signalling in the regulation and resolution of acute inflammation

该研究涉及探索TNFR1和TNFR2在急性炎症中的信号传导，特别关注这些受体在肺中的作用。研究通过TNFR1信号传导的器官损伤机制以及使用域抗体抑制TNFR1是否可以预防肺损伤的发生。该项目的另一个方面包括研究下游TNFR2信号传导以及它如何在炎症期间提供保护。

The research involves the exploration of TNFR1 and TNFR2 signalling in acute inflammation, looking particularly at the roles of these receptors in the lung. Investigation on mechanisms of organ injury via TNFR1 signalling and whether inhibition of TNFR1 using a domain antibody can prevent the development of lung injury. Another aspect of the project includes investigation of downstream TNFR2 signalling and how it may provide protection to during inflammation.