Rheumatology Training Grant

描述(由申请人提供)： 研究培训补助金的目的是为医学博士和博士后研究员提供基本的研究背景。这一培训将是迈向学术医学职业生涯的关键一步，并将帮助研究员为成为独立调查人员做好准备。风湿病集团的一个优势是在基础生物医学研究以及流行病学和临床研究方面都有相当大的深度和生产力。最近的教师招聘为分子生物学做出了贡献，分子生物学的研究重点是基因转录的调节、硬皮病的成纤维细胞生物学和胶原调节以及mRNA剪接。在免疫学方面，几名高级研究人员研究了自身免疫动物模型中的淋巴细胞凋亡、巨噬细胞缺陷和细胞-细胞黏附。在淀粉样变性中，有关于淀粉样蛋白纤维形成和转甲状腺素基因突变的研究。最后，还有关于骨质疏松症、骨性关节炎和类风湿性关节炎的杰出流行病学和结果研究，关于风湿性疾病的卫生经济学研究和决策分析，以及关于淀粉样变性和硬皮病的临床研究。研究员有各种各样的培训机会，使用最先进的方法研究风湿病的分子基础、发病机制和进展。培训的技术方面将包括分子和细胞生物学、免疫学以及疾病的分析统计和流行病学方法方面的技术。尽管在基础科学和卫生服务研究方面的培训经验会有两极分化，但这些领域的互动和交叉交流将使受训人员从整体上更好地了解疾病。在补助金的每一年为3名学员申请资金，每个学员在培训方案中花费两到三年的时间。波士顿大学的这个项目在风湿学博士后培训方面有着出色的记录，许多毕业生都获得了杰出的学术职位。教员们提供了一种强有力的、经验丰富的方法，并将把他们的才华奉献给培训补助金。

DESCRIPTION(Provided by Applicant): The purpose of the Research Training Grant is to provide a fundamental background in research to M.D. and Ph.D. post-doctoral fellows. This training will be a critical step towards a career in academic medicine and will help prepare fellows to become independent investigators. A strength of the Rheumatology group is the considerable depth and productivity in both basic biomedical research and in epidemiology and clinical research. Recent faculty recruitments have contributed to substantial strengths in molecular biology where research focuses on regulation of gene transcription, on fibroblast biology and collagen regulation in scleroderma, and on mRNA splicing. In immunology, several senior investigators examine lymphocyte apoptosis, macrophage defects in autoimmune animal models and cell-cell adhesion. In amyloidosis, there are studies of amyloid fibrillogenesis and of mutations in transthyretin genes. Finally, there are outstanding epidemiologic and outcome studies of osteoporosis, osteoarthritis and rheumatoid arthritis and studies of health economics and decision analysis in rheumatic diseases and clinical studies in amyloidosis and scleroderma. Fellows have a diversity of training opportunities to use state of the art approaches in the study of molecular basis, pathogenesis and progress of rheumatic disease. Technical aspects of training will include techniques in molecular and cell biology, immunology, and analytical statistical and epidemiological approaches to disease. Although there will be a dichotomy between training experiences of those in basic bench sciences and in health services research, the interaction and crossfertilization of these areas will allow trainees to gain an overall greater understanding of disease. Funding is requested for 3 trainees in each year of the grant, each trainee to spend two to three years in the training program. The program at Boston University has a distinguished record of post-doctoral training in rheumatology and many graduates have gone on to distinguished academic positions. The faculty provide a strong and experienced approach and will devote their talents to the training grant.