Exploring differences in NETosis in systemic lupus erythematosus (SLE)

探索系统性红斑狼疮 (SLE) NETosis 的差异

• 批准号: 2294875
• 金额: --
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2294875
• 关键词: Exploring; differences; NETosis; systemic; lupus

Systemic lupus erythematosus (SLE) is an autoimmune disorder predominantly affecting women. Importantly the clinical features of this disease are highly heterogeneous which offers the potential for personalised therapies.Recently it has been identified that neutrophils can extrude their contents through as a neutrophil extracellular trap (NET). These are potent immune system stimulators and may drive the inflammatory process in SLE. Furthermore, difference between when and how NETs form may explain some of the clinical and immunological variation in SLE. This project will explore novel aspects of NET function in patients with SLE. In collaboration with the industrial partner wewill use high throughput fluorescent microscopy to study both NET formation and removal. Variation in NET content and the consequences for downstream immune activity will be identified. Finally the development of high throughput assayswill allow us to screen drug libraries for novel modulators of NET formation and function. We aim to identify novel treatments for SLE along with a robust approach for personalisation of treatment.

系统性红斑狼疮（SLE）是一种自身免疫性疾病，主要影响妇女。重要的是，这种疾病的临床特征是高度异质性的，这为个性化治疗提供了可能性。最近已经确定，中性粒细胞可以通过中性粒细胞胞外陷阱（NET）挤出其内容物。这些都是有效的免疫系统刺激剂，并可能推动SLE的炎症过程。此外，NETs形成的时间和方式的差异可以解释SLE的一些临床和免疫学变化。本项目将探讨SLE患者NET功能的新方面。在与工业合作伙伴的合作中，我们将使用高通量荧光显微镜来研究NET的形成和去除。NET含量的变化和下游免疫活性的后果将被确定。最后，高通量分析的发展将使我们能够筛选NET形成和功能的新型调节剂的药物库。我们的目标是确定新的治疗系统性红斑狼疮沿着一个强大的方法，个性化的治疗。